Relationship between hyperuricemia and metabolic syndrome
Li-ying Chen1, Wen-hua Zhu, Zhou-wen Chen
1Department of Family Medicine, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou 310016, China. cly0906@163.com
Journal of Zhejiang University. Science. B
|July 28, 2007
Summary
Hyperuricemia is common and linked to metabolic syndrome in the Chinese population. Elevated uric acid levels increase the risk of developing metabolic syndrome in both men and women.
Area of Science:
- Clinical Medicine
- Cardiovascular Health
- Metabolic Disorders
Background:
- Hyperuricemia is a condition of elevated uric acid levels.
- Metabolic syndrome is a cluster of conditions increasing heart disease, stroke, and diabetes risk.
Purpose of the Study:
- To investigate the relationship between hyperuricemia and metabolic syndrome.
- To determine the prevalence of hyperuricemia and its association with metabolic syndrome components.
Main Methods:
- A total of 2,374 subjects were analyzed.
- Hyperuricemia was defined as uric acid levels ≥7 mg/dl (men) or ≥6.0 mg/dl (women).
- Metabolic syndrome was diagnosed using AHA/NHLBI criteria.
Main Results:
- The prevalence of hyperuricemia was 13.10%, higher in men (19.07%) than women (3.42%).
- In men, uric acid correlated positively with waist circumference, blood pressure, and triglycerides, and negatively with HDL-C.
- In women, uric acid correlated positively with waist circumference, triglycerides, and fasting plasma glucose.
- Hyperuricemia was associated with a 1.63-fold increased risk of metabolic syndrome in men and a 1.62-fold increased risk in women.
Conclusions:
- Hyperuricemia is prevalent in the Chinese population.
- Serum uric acid is positively associated with metabolic syndrome.
- Hyperuricemia is a significant risk factor for metabolic syndrome.
Related Concept Videos
01:29Hyperglycemia
Hyperglycemia is an abnormally high blood glucose level. It is diagnosed by fasting glucose ≥126 mg/dL, 2-hour oral glucose tolerance test (or OGTT) ≥200 mg/dL, random glucose ≥200 mg/dL with symptoms, or HbA1c ≥6.5%. However, HbA1c results may be unreliable in certain conditions, such as anemia or hemoglobinopathies, and the diagnosis should be confirmed unless classic symptoms are present. Postprandial hyperglycemia is typically considered significant when glucose levels exceed 180 mg/dL two...
01:19Overview of Carbohydrate Metabolism
Carbohydrate metabolism is a fundamental biochemical process that ensures a constant supply of energy to living cells. The most important carbohydrate is glucose, which can be broken down via glycolysis to enter into the Krebs cycle and eventually lead to the production of ATP through oxidative phosphorylation.
Glucose transport into cells is facilitated by a family of transport proteins called GLUT (Glucose Transporters). GLUT4 is the primary glucose transporter for insulin-stimulated glucose...
Glucose transport into cells is facilitated by a family of transport proteins called GLUT (Glucose Transporters). GLUT4 is the primary glucose transporter for insulin-stimulated glucose...
01:27Hyperthyroidism II: Pathophysiology
Hyperthyroidism is a hypermetabolic state caused by elevated levels of thyroid hormones, triiodothyronine (T3) and thyroxine (T4). It results from dysregulation at the thyroid, pituitary, or immune system level and affects multiple organ systems.PathophysiologyThe most common cause of hyperthyroidism is Graves’ disease, an autoimmune disorder in which antibodies, specifically thyroid-stimulating antibodies (TSAb), a subtype of TSH receptor antibodies (TRAb), bind to and activate TSH receptors...
01:21Hyperosmolar Hyperglycemic State
Hyperosmolar Hyperglycemic State, or HHS, is a serious and life-threatening complication of type 2 diabetes mellitus. It is characterized by three main features: severe hyperglycemia, profound dehydration, and elevated serum osmolality, all occurring without significant ketoacidosis.HHS typically develops in older adults or individuals with limited access to fluids. This may result from illness, cognitive impairment, or medications such as diuretics or corticosteroids. These factors reduce...
01:29Cholesterol: Significance and Regulation
Although not a source of energy, cholesterol plays a significant role as a foundational structure for bile salts, steroid hormones, and vitamin D, as well as being a crucial component of plasma membranes. Approximately 15% of blood cholesterol is derived from our diet, with the remainder synthesized from acetyl CoA by the liver and intestines. Cholesterol is eliminated from the body through its conversion into bile salts, which are eventually discarded in the feces.
Considering cholesterol and...
Considering cholesterol and...
01:24Nephrotic Syndrome I : Introduction
Nephrotic Syndrome is a chronic kidney disorder defined by clinical findings such as severe proteinuria, hypoalbuminemia, hyperlipidemia, and edema. These symptoms result from damage to the glomeruli, the kidney’s filtering units, increasing their permeability to proteins.Definition and Meaning:Proteinuria, defined as the loss of more than 3.5 grams of protein per day in adults, is a crucial feature of nephrotic syndrome. This condition is often accompanied by edema, the accumulation of fluid...