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Related Experiment Video

Updated: Jun 26, 2026

Cultivating a Three-dimensional Reconstructed Human Epidermis at a Large Scale

Cultivating a Three-dimensional Reconstructed Human Epidermis at a Large Scale

Published on: May 28, 2021

Cell proliferation and differentiation during epidermis renewal.

Kai Liu^1,2, Kaidi Ren³, Dengwen Li⁴

¹Department of Translational Medicine Center, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China.

Journal of Zhejiang University. Science. B

|June 25, 2026

Summary

Epidermal renewal relies on stem cell proliferation and differentiation, crucial for skin barrier function. Advanced techniques like single-cell omics and AI modeling are key to understanding these complex processes.

Keywords:

Asymmetric cell division Basement membrane dynamics Epidermis renewal Mechanotransduction Single-cell omics Stem cell proliferation

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Related Experiment Videos

Last Updated: Jun 26, 2026

Cultivating a Three-dimensional Reconstructed Human Epidermis at a Large Scale

Cultivating a Three-dimensional Reconstructed Human Epidermis at a Large Scale

Published on: May 28, 2021

Generation of Genetically Modified Organotypic Skin Cultures Using Devitalized Human Dermis

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Published on: December 14, 2015

Live Cell Imaging with Time Lapse Photography to Study Epidermal Keratinocyte Proliferation Kinetics

Live Cell Imaging with Time Lapse Photography to Study Epidermal Keratinocyte Proliferation Kinetics

Published on: June 6, 2025

Area of Science:

Dermatology and Stem Cell Biology
Cellular and Molecular Biology

Background:

The epidermis, the skin's outer layer, requires constant renewal for barrier integrity.
Epidermal renewal depends on the precise proliferation and differentiation of basal stem cells.
This renewal is regulated by intrinsic cell division and external microenvironmental cues.

Purpose of the Study:

To review the critical processes governing epidermis renewal.
To emphasize the balance between symmetric and asymmetric stem cell division.
To highlight the role of advanced technologies in understanding epidermal renewal.

Main Methods:

Review of current literature on epidermal renewal mechanisms.
Discussion of single-cell omics technologies.
Integration of live imaging and artificial intelligence (AI)-driven modeling approaches.

Main Results:

The review details the complex interplay of factors regulating epidermal stem cell fate.
It highlights the importance of balancing symmetric and asymmetric cell divisions for tissue homeostasis.
The integration of differentiated cells into the suprabasal layer is examined.

Conclusions:

Understanding epidermal renewal requires integrating molecular, cellular, and microenvironmental data.
Advanced techniques like single-cell omics, live imaging, and AI modeling are crucial for future research.
Precise regulation of stem cell proliferation and differentiation is vital for maintaining skin barrier function.