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Updated: Jul 12, 2026
12:23
Granulocyte-dependent Autoantibody-induced Skin Blistering
Published on: October 12, 2012
Pathogenesis and clinical features of psoriasis
Christopher Em Griffiths1, Jonathan Nwn Barker2
1Dermatology Centre, Hope Hospital, University of Manchester, Manchester M6 8HD, UK.
Lancet (London, England)
|July 31, 2007
Summary
Psoriasis is an immune-mediated skin disease involving epidermal keratinocytes, T-cells, and tumor necrosis factor alpha. Understanding its pathogenesis and comorbidities like psoriatic arthritis is key to developing new treatments.
Area of Science:
- Immunodermatology
- Genetics
- Pathophysiology
Background:
- Psoriasis, a papulosquamous disease, is now recognized as a common immune-mediated disorder.
- Tumor necrosis factor alpha, dendritic cells, and T-cells are key contributors to psoriasis pathogenesis.
- Early-onset psoriasis is influenced by HLA-Cw6 and environmental factors like streptococcal infections.
Purpose of the Study:
- To review the pathogenesis of psoriasis.
- To discuss the genetic and environmental determinants of psoriasis.
- To explore the comorbidities associated with psoriasis.
Main Methods:
- Review of current literature on psoriasis pathogenesis.
- Analysis of genetic susceptibility loci for psoriasis.
- Examination of clinical phenotypes and comorbidities of psoriasis.
Main Results:
- Psoriasis involves complex immune pathways and genetic factors.
- HLA-Cw6 carriage and infections are significant in early-onset disease.
- Chronic plaque psoriasis (psoriasis vulgaris) is the most common form.
- Comorbidities include impaired quality of life, depression, cardiovascular disease, and psoriatic arthritis.
Conclusions:
- A comprehensive understanding of psoriasis pathomechanisms is advancing treatment strategies.
- Psoriasis is a multifaceted immune-mediated condition with significant comorbidities.
- Further research into underlying mechanisms will drive therapeutic innovation.
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