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Enhancing exposure-based therapy from a translational research perspective.

Stefan G Hofmann¹

¹Department of Psychology, Boston University, 648 Beacon Street, 6th Floor, Boston, MA 02215-2002, USA. shofmann@bu.edu

Behaviour Research and Therapy

|July 31, 2007

Summary

D-cycloserine (DCS) may enhance fear reduction during exposure therapy for anxiety disorders by facilitating extinction learning. This augmentation strategy shows promise, though further research is needed.

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Area of Science:

Neuroscience
Psychology
Pharmacology

Background:

Anxiety disorders are commonly treated with psychological therapy or medication, but combining them is not always superior.
Advances in fear reduction neuroscience suggest novel therapeutic combinations.
Exposure therapy relies on extinction to reduce fear responses.

Purpose of the Study:

To discuss the mechanisms of extinction learning.
To explore the therapeutic potential of D-cycloserine (DCS) in augmenting exposure therapy.
To identify future research directions.

Main Methods:

Review of animal and human studies on D-cycloserine (DCS).
Discussion of biological and psychological mechanisms of extinction learning.
Analysis of DCS as a partial agonist at the glycine recognition site of the N-methyl-D-aspartate receptor.

Main Results:

D-cycloserine (DCS) has been shown to facilitate extinction learning in animal models.
Human trials indicate that DCS enhances fear reduction during exposure therapy for certain anxiety disorders.
DCS acts as a partial agonist, potentially improving therapeutic outcomes.

Conclusions:

D-cycloserine (DCS) shows promise as an augmentation strategy for exposure therapy.
Understanding extinction learning mechanisms is crucial for developing effective anxiety treatments.
Further research is warranted to fully elucidate the role of DCS in anxiety treatment.