Related Experiment Video
Updated: Jul 13, 2026

06:13
Using Home-based, Remotely Supervised, Transcranial Direct Current Stimulation for Phantom Limb Pain
Published on: March 1, 2024
Treatment of CRPS with ECT
Marie Wojcik Wolanin1, Vasko Gulevski, Robert J Schwartzman
1Drexel University College of Medicine, Philadelphia, PA 19102-1192, USA.
Pain Physician
|July 31, 2007
Summary
Electroconvulsive therapy (ECT) effectively treated a patient with severe depression and Complex Regional Pain Syndrome (CRPS). The treatment resolved both the patient's depressive and CRPS symptoms, offering a novel therapeutic avenue.
Area of Science:
- Neurology
- Psychiatry
- Pain Management
Background:
- Electroconvulsive therapy (ECT) is a recognized treatment for drug-resistant depression.
- ECT has a history of use in pain management, though its mechanisms remain unclear.
- Previous reports suggest ECT may alleviate Complex Regional Pain Syndrome (CRPS) symptoms in patients with comorbid depression.
Observation:
- A case study involved a 42-year-old female patient diagnosed with medically refractory depression and CRPS.
- The patient received 12 sessions of standard bitemporal ECT for her depression.
- Pre- and post-treatment assessments included physical examination and Quantitative Sensory Testing (QST).
Findings:
- ECT successfully resolved the patient's depressive symptoms.
- The patient experienced complete reversal of her CRPS symptoms following ECT.
- QST and physical examination findings corroborated the improvement in CRPS symptoms post-ECT.
Implications:
- This case suggests ECT may be a viable treatment for severe, refractory CRPS.
- Further research is warranted to explore the efficacy and mechanisms of ECT in treating CRPS.
- ECT could offer a therapeutic option for patients with co-occurring depression and CRPS.

