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Published on: February 20, 2020
Co-operative effect of Lewis acids with transition metals for organic synthesis
1Beijing National Laboratory for Molecular Sciences, Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education, College of Chemistry, Peking University, Beijing 100871, China.
Abstract:
Transition metal-mediated or -catalyzed carbon-carbon bond or carbon-heteroatom bond forming reactions are among the most powerful tools in organic synthesis. In addition, Lewis acid-mediated or -catalyzed organic transformations are widely used. In this context, an effective combination of these two powerful protocols or an efficient cooperation of transition metals with Lewis acids should open a new era in synthetic chemistry. This tutorial review summarizes representative synthetic methodologies developed in the past decades employing this co-operative effect.
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