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Updated: Jul 13, 2026
In vivo Imaging of the Mouse Spinal Cord Using Two-photon Microscopy
Published on: January 5, 2012
In vivo mouse spinal cord imaging using echo-planar imaging at 11.75 T
Virginie Callot1, Guillaume Duhamel, Patrick J Cozzone
1Centre de Résonance Magnétique Biologique et Médicale (CRMBM), UMR CNRS, Faculté de Médecine de Marseille, Université de la Méditerranée, 27 Bd Jean Moulin, 13385, Marseille Cedex 5, France. virginie.callot@medecine.univ-mrs.fr
Object:
To evaluate the feasibility of mouse spinal cord MR imaging using echo-planar imaging (EPI).
Materials And Methods:
Optimized multi-shot spin-echo-EPI sequences were compared to conventional spin-echo (c-SE) at 11.75 T and used for high-spatially resolved acquisitions and relaxation-time measurements.
Results:
Good quality images were obtained, with clear delineation of gray and white matter. Acquisition-time gain factor was up to 6 (vs. c-SE) and resolution up to 74 x 94 microm2 was achieved. T1 and T2 relaxation times were reliably measured.
Conclusion:
High-temporally and spatially resolved mouse spinal cord EPI imaging is feasible. This technique should greatly benefit to long acquisition-time experiments (diffusion imaging) and imaging of rapidly-evolving pathologies.
