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Brain tau expression and correlation with the H1/H1 tau genotype in frontotemporal lobar degeneration patients

A Lladó1, M Ezquerra, C Gaig

  • 1Alzheimer's Disease and Other Cognitive Disorders Unit, Service of Neurology, Hospital Clínic and Institut d'Investigació Biomèdica August Pi i Sunyer (IDIBAPS), Barcelona, Spain.

Journal of Neural Transmission (Vienna, Austria : 1996)
|July 31, 2007
PubMed

Insights

Frontotemporal lobar degeneration (FTLD) patients did not show altered tau mRNA splicing. However, the H1/H1 tau genotype was linked to increased 4R/3R tau mRNA ratios, suggesting a role in modulating tau splicing.

Area of Science:

  • Neuroscience
  • Genetics
  • Molecular Biology

Background:

  • Sporadic tauopathies are associated with tau mRNA splicing alterations.
  • The H1/H1 tau genotype is implicated in some tauopathies.

Purpose of the Study:

  • To investigate the 4R/3R tau mRNA ratio in frontotemporal lobar degeneration (FTLD).
  • To determine the influence of the H1/H1 tau genotype on this ratio.

Main Methods:

  • Analysis of the 4R/3R tau mRNA ratio in the frontal cortex of 18 FTLD patients and controls.
  • Genotyping for the H1/H1 tau genotype.

Main Results:

  • The 4R/3R tau mRNA ratio was comparable between FTLD patients and control groups.
  • H1/H1 genotype carriers exhibited a significant elevation in the 4R/3R mRNA ratio.

Conclusions:

  • The H1/H1 tau genotype may play a role in modulating tau mRNA splicing.
  • This finding suggests a potential genetic influence on tau pathology in FTLD.

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