Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Refining the predictive pursuit endophenotype in schizophrenia.

L Elliot Hong1, Kathleen A Turano, Hugh O'Neill

  • 1Maryland Psychiatric Research Center, Lions Vision Center, Johns Hopkins School of Medicine, Baltimore, Maryland 21228, USA. ehong@mprc.umaryland.edu

Biological Psychiatry
|July 31, 2007
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Retinal Vasculature in Schizophrenia Spectrum Disorder.

Bioengineering (Basel, Switzerland)·2026
Same author

Shared genetic architecture of brain age gap across 30 cohorts worldwide.

medRxiv : the preprint server for health sciences·2026
Same author

Role of childhood trauma in interoception and alexithymia in schizophrenia.

Journal of psychiatric research·2025
Same author

Striatum volume and affective symptomatology are associated with sleep in schizophrenia.

Journal of psychiatric research·2025
Same author

Neutrons reveal the dynamics of leaf thylakoids in living plants.

Scientific reports·2025
Same author

Family History of Substance Use and Stressful Life Events Impact Adolescent Maturation of Cerebral White Matter.

Addiction biology·2025

Schizophrenia patients and their relatives show impaired predictive smooth pursuit eye movements, suggesting a deficit in internal motion representation. This eye-tracking abnormality may stem from genetic factors common in schizophrenia families.

Area of Science:

  • Neuroscience
  • Psychiatry
  • Genetics

Background:

  • Smooth pursuit eye movements are an endophenotype of schizophrenia, but the specific deficit remains unclear.
  • Previous studies indicated reduced predictive pursuit in schizophrenia, potentially confounded by target awareness.
  • Identifying the precise physiologic deficit is crucial for gene discovery and neurobiological studies in schizophrenia.

Purpose of the Study:

  • To investigate the nature of smooth pursuit abnormalities in schizophrenia using a novel covert foveal stabilization technique.
  • To compare predictive pursuit eye movements in schizophrenia patients, their relatives, and healthy controls.

Main Methods:

  • A novel method covertly stabilized the moving target image onto the fovea during smooth pursuit.
  • Foveal stabilization occurred when eye velocity reached zero near direction changes, ensuring predictive, internally driven pursuit.

Related Experiment Videos

  • Eye velocity was compared between schizophrenia patients (n=45), unaffected first-degree relatives (n=42), and healthy controls (n=22).

    • Main Results:

    • Schizophrenia patients and their unaffected relatives exhibited similarly reduced predictive pursuit acceleration and velocity.
    • The foveally stabilized condition revealed significant impairments in predictive smooth pursuit within schizophrenia families.

    Conclusions:

    • The findings suggest a deficit in maintaining internal target motion representations or integrating this information for predictive responses.
    • This refined smooth pursuit measure may index a specific brain deficit and a less complex genetic origin of eye-tracking abnormalities in schizophrenia.
    • The shared deficit between patients and relatives highlights potential genetic underpinnings of these neurobiological markers.