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Updated: Jul 13, 2026

A Model for Perineural Invasion in Head and Neck Squamous Cell Carcinoma
Published on: January 5, 2017
Squamous cell carcinoma in the head and neck
Hiba Al-Reefy1, Vikram Dhar, Mike Dilkes
1Ear Nose Throat and Head and Neck Surgery, St Bartholomew's Hospital, London.
Head and neck cancers affect 10% of UK males, with the incidence gap between men and women narrowing significantly. This review covers their clinical presentation and treatment strategies.
Area of Science:
- Oncology
- Public Health
Background:
- Head and neck cancers represent 10% of male cancer diagnoses in the UK.
- Historically, male incidence was 6-7 times higher than female incidence.
Purpose of the Study:
- To review the current presentation of head and neck cancers.
- To outline the management strategies for these malignancies.
Main Methods:
- Literature review of head and neck cancer epidemiology.
- Synthesis of clinical presentation and management guidelines.
Main Results:
- The male-to-female incidence ratio has decreased to approximately 2:1.
- The article provides an overview of common clinical signs and symptoms.
- Standard treatment modalities are discussed.
Conclusions:
- Head and neck cancer epidemiology is shifting, with a reduced male predominance.
- Effective management requires understanding evolving presentation and treatment options.
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