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Progeria (Hutchison-Gilford syndrome) in siblings: in an autosomal recessive pattern of inheritance
T Y Raghu1, G A Venkatesulu, G R Kantharaj
1Department of Skin and Sexually Transmitted Diseases, Viydyanagar Institute of Medical Sciences, Government Medical College, Bellary-583 104, Karnataka, India.
Abstract:
Progeria is an autosomal dominant, premature aging syndrome. Six and three year old female siblings had sclerodermatous changes over the extremities, alopecia, beaked nose, prominent veins and bird-like facies. Radiological features were consistent with features of progeria. The present case highlights rarity of progeria in siblings with a possible autosomal recessive pattern.
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