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Bacteriological spectrum of cholecystitis and its antibiogram
M Ballal1, K N Jyothi, B Antony
1Department of Microbiology, Kasturba Medical College, Manipal - 576 119, Karnataka, India.
Indian Journal of Medical Microbiology
|August 1, 2007
Summary
Bile cultures from patients with chronic cholecystitis and gallstones frequently revealed aerobic and anaerobic bacteria. Escherichia coli and Bacteroides fragilis were the most common pathogens identified in this study.
Area of Science:
- Microbiology
- Gastroenterology
- Infectious Diseases
Background:
- Chronic cholecystitis with cholelithiasis is a common condition.
- Bile infection is a significant factor in the pathogenesis and recurrence of gallstone disease.
Purpose of the Study:
- To investigate the microbiological profile of bile in patients with chronic cholecystitis and cholelithiasis.
- To identify the predominant aerobic and anaerobic bacteria involved in these infections.
Main Methods:
- Bile samples from 125 patients were cultured for aerobic and anaerobic bacteria.
- Bacterial identification and susceptibility testing were performed.
Main Results:
- Bacterial growth was observed in 71 (56.8%) aerobic and 17 (13.6%) anaerobic cultures.
- Polymicrobial infections occurred in 7 (16.2%) cases.
- Escherichia coli (45.07%) and Klebsiella (25.35%) were the most common aerobes.
- Bacteroides fragilis (58.82%) was the predominant anaerobe.
- The highest disease incidence was in the fourth decade of life, with a female predominance.
Conclusions:
- Bile cultures are valuable in diagnosing bacterial infections associated with chronic cholecystitis and cholelithiasis.
- Aerobic and anaerobic bacteria, particularly E. coli and B. fragilis, frequently contaminate bile in these patients.
- Understanding the microbial spectrum can guide targeted antimicrobial therapy and improve patient outcomes.
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