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Related Experiment Videos

[Erythrocyte viscosity-deformability-aggregation. A clinical reality].

A Cortinovis1, A Crippa

  • 1Dipartimento di Medicina Interna, Università degli Studi di Pavia.

Minerva Medica
|November 1, 1991
PubMed
Summary
This summary is machine-generated.

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This study introduces a simple method to measure blood viscosity fractions, crucial for understanding vascular pathologies. The technique quantizes viscosity, aiding in assessing red blood cell deformability and guiding drug therapy.

Area of Science:

  • Hematology
  • Biophysics

Context:

  • Vascular pathologies necessitate accurate blood viscosity measurements for effective drug therapy.
  • Current methods may lack on-the-spot or site-specific applicability.

Purpose:

  • To present an easily performed calculation method for measuring blood viscosity fractions.
  • To quantify total blood viscosity, corpuscular viscosity, and plasma-erythrocytic viscosity using Reid's technique and hematic filterability.
  • To establish erythrocytic deformability as a reliable parameter for pathological and pharmacological assessment.

Summary:

  • The proposed method utilizes hematic filterability through varied pore sizes to determine blood viscosity components.
  • Viscosity fractions (total, corpuscular, plasma-erythrocytic) are quantified in centipoise (cP), independent of blood concentration.

Related Experiment Videos

  • Erythrocytic deformability is assessed as a percentage, showing a narrow range in controls and utility in pathological cases like thalassemia.

    • Impact:

    • Provides a functional flow datum and a reliable marker for assessing pathological and pharmacological changes in blood viscosity.
    • Offers a practical tool for clinicians to measure blood viscosity components relevant to vascular disease management.
    • Demonstrates the clinical relevance using thalassemia as a model for erythrocytic morphological changes.