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Molecular typing methods for minor histocompatibility antigens

Eric Spierings1, Els Goulmy

  • 1Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, Leiden, The Netherlands.

Methods in Molecular Medicine
|August 2, 2007
PubMed

Minor histocompatibility (H) antigens crucially affect the outcome of human leukocyte antigen-matched allogeneic stem cell transplantation. The number of molecularly identified minor H antigens is rapidly increasing. In parallel, clinical implementation of minor H antigens for immunotherapy has gained significant interest. It is therefore timely to type stem cell transplant recipients and their donors for minor H antigens. Here, we summarize all the currently known methodologies for minor H antigen typing on the genomic and on the RNA level.

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