Cylindroma of the prostate

Area of Science:

• Oncology
• Pathology
• Urology

Background:

• Prostate cancer diagnosis relies on identifying specific cellular and architectural features.
• Basaloid proliferative lesions of the prostate are uncommon and require precise classification.
• Dermal cylindroma is a rare benign adnexal tumor typically found in the skin.

Observation:

• A 78-year-old man presented with a sporadic prostate tumor.
• The tumor exhibited morphological and immunophenotypical characteristics similar to dermal cylindroma.
• Histological examination revealed basaloid epithelial islands with prominent basement membrane material and alpha-smooth muscle actin expression.

Findings:

• The prostate tumor was histologically identical to dermal cylindroma, marking a novel finding.
• A key distinguishing feature was the absence of intratumoral Langerhans cells, unlike typical dermal cylindromas.
• The neoplasm was readily differentiated from other known basal cell proliferative lesions of the prostate.

Implications:

• This case expands the spectrum of prostate neoplasms.
• Recognizing cylindroma-like features in prostate tumors is crucial for accurate diagnosis.
• Further research may elucidate the potential origins and behavior of such rare prostate tumors.