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Chemoselective derivatization of alkaloids in periwinkle

M Carmen Galan1, Elizabeth McCoy, Sarah E O'Connor

  • 1Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA.

Chemical Communications (Cambridge, England)
|August 2, 2007
PubMed

Abstract:

The terpene indole alkaloid biosynthetic pathway can utilize a secologanin substrate analog containing a handle for functionalization, and the resulting non-natural alkaloids can be chemoselectively derivatized in crude extracts of plant tissue.

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