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Published on: June 21, 2024
Imaging in childhood urinary tract infections: time to reduce investigations
Stephen D Marks1, Isky Gordon, Kjell Tullus
1Department of Paediatric Nephrology, Great Ormond Street Hospital for Children NHS Trust, Great Ormond Street, London WC1N 3JH, UK. markss2@gosh.nhs.uk
Insights
Investigating childhood urinary tract infections (UTI) can be simplified. A targeted approach focusing on high-risk children is effective and avoids unnecessary tests, reducing distress and costs.
Area of Science:
- Pediatrics
- Nephrology
- Infectious Diseases
Background:
- Childhood urinary tract infections (UTI) are common.
- The primary goal of UTI investigation is to prevent long-term complications like hypertension and chronic kidney disease (CKD).
- Epidemiological studies indicate a low risk of these sequelae from childhood UTIs.
Purpose of the Study:
- To review current literature on childhood UTI investigations.
- To propose a protocol for targeted investigations in high-risk children.
- To identify children with an increased risk of abnormal urinary tracts.
Main Methods:
- Literature review of current UTI investigation protocols.
- Analysis of risk factors for long-term complications.
- Development of a selective investigation strategy for high-risk pediatric patients.
Main Results:
- Childhood UTI is common, but progression to CKD is rare.
- Current investigation protocols may lead to unnecessary procedures.
- A targeted approach can safely and effectively identify high-risk children.
Conclusions:
- Targeted investigations in high-risk children are clinically safe and effective.
- This approach avoids unnecessary distress and costs associated with invasive tests.
- A selective investigation protocol is recommended over universal screening for childhood UTI.
Abstract:
The correct protocol for investigating urinary tract infections (UTI) is unknown but remains a hotly debated topic. The main objective in investigating children with UTI is to prevent the long-term complications of developing hypertension, chronic kidney disease (CKD) and/or pregnancy complications. However, the prognosis for childhood UTI remains good, with low long-term risks, from epidemiological studies, of developing these sequelae. Although childhood UTI is common, the occurrence of CKD and the likelihood that acute pyelonephritis will cause renal damage progressing to CKD are rare. We studied the current literature on investigations of childhood UTI and propose a protocol for carrying out selected investigations in high-risk children. By identifying this group of children with increased risk of having an abnormal urinary tract that warrant investigation, we recommend that targeting investigations to specific children (as opposed to protocol-based investigations of all children with UTI), will be clinically safe and effective and will avoid the unnecessary distress and cost of invasive investigations.
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