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Related Experiment Video

Updated: Jul 13, 2026

Quantification of Hypopigmentation Activity In Vitro

Quantification of Hypopigmentation Activity In Vitro

Published on: March 6, 2019

[Capecitabine-induced hyperpigmentation].

C Vázquez-Bayo¹, A L Rodríguez-Bujaldón, R Jiménez-Puya

¹Servicio de Dermatología, Hospital Universitario Reina Sofía, Córdoba, España.

Actas Dermo-Sifiliograficas

|August 3, 2007

Summary

Capecitabine, an antineoplastic drug, can cause localized skin hyperpigmentation, particularly on the hands and feet. This case report highlights a rare side effect of capecitinib therapy in breast cancer patients.

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Area of Science:

Oncology
Dermatology
Pharmacology

Background:

Capecitabine is a widely used oral chemotherapeutic agent for metastatic breast and colon cancers.
Adverse effects, including mucocutaneous toxicities, are known complications of capecitabine treatment.
Skin hyperpigmentation is a recognized, though less common, adverse effect.

Observation:

A case of localized cutaneous hyperpigmentation is presented in a breast cancer patient undergoing capecitabine therapy.
The patient developed hyperpigmentation of the hands and feet after one month of treatment.
Concurrent dysesthesias were also noted at the onset of hyperpigmentation.

Findings:

The observed hyperpigmentation was localized to the hands and feet, appearing after a month of capecitabine administration.
The exact pathogenesis of capecitabine-induced localized hyperpigmentation remains unclear.
Other nail-related adverse effects like onycholysis and dystrophy are also associated with this drug.

Implications:

This case underscores the importance of monitoring for mucocutaneous side effects during capecitabine therapy.
Increased awareness of localized hyperpigmentation can aid in early diagnosis and management.
Further research into the mechanisms of capecitabine-induced skin toxicities is warranted.