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Updated: Jul 13, 2026

Yeast As a Chassis for Developing Functional Assays to Study Human P53

Yeast As a Chassis for Developing Functional Assays to Study Human P53

Published on: August 4, 2019

p53 codon 72 polymorphism in patients affected with ulcerative colitis.

Maria Teresa Vietri¹, Gabriele Riegler, Antonietta Ursillo

¹Department of General Pathology, Chair of Clinical Pathology, Second Medical School of Naples, Via L De Crecchio, 7-80138, Naples, Italy.

Journal of Gastroenterology

|August 3, 2007

Summary

The p53 Arg72Pro polymorphism is linked to ulcerative colitis (UC) duration and clinical course. Pro homozygosity is associated with longer disease duration and a higher risk of colorectal cancer in UC patients.

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Area of Science:

Genetics
Oncology
Gastroenterology

Background:

The p53 tumor suppressor protein is crucial for genomic integrity, cell cycle arrest, and apoptosis.
Polymorphisms in the p53 gene, particularly at codon 72, have been controversially linked to cancer predisposition.
The role of p53 Arg72Pro polymorphism in ulcerative colitis (UC) clinical parameters requires further investigation.

Purpose of the Study:

To investigate the association between the p53 Arg72Pro polymorphism and clinical parameters in patients with ulcerative colitis (UC).

Main Methods:

A cohort of 243 UC outpatients and 142 healthy controls were genotyped for the p53 Arg72Pro polymorphism.
Clinical data, including disease duration and family history of colorectal carcinoma (CRC), were collected and analyzed.

Main Results:

p53 Pro/Pro genotype was significantly associated with longer disease duration (odds ratio, 55.8) and continuous disease course in UC patients.
Patients with Pro homozygosity showed a higher prevalence of long-standing UC (>7 years) compared to Arg/Arg and Arg/Pro genotypes.
p53 Pro/Pro was also significantly linked to a positive family history of CRC (odds ratio, 38.1) among UC patients.

Conclusions:

The p53 Arg72Pro polymorphism appears to influence the clinical course of UC.
p53 Pro homozygosity is associated with continuous disease and may indicate an increased risk for colorectal carcinoma in UC patients.