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The 4-vessel Sampling Approach to Integrative Studies of Human Placental Physiology In Vivo
12:17

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[Hemostatic system parameters of placental extracts in normal pregnancy and severe preeclampsia]

Ysabel López-Ramírez1, Zoila Carvajal, Carmen Luisa Arocha-Piñango

  • 1Centro de Bioquímica y Biofísica y Centro de Medicina Experimental, Instituto Venezolano de Investigaciones Científicas, Caracas, Venezuela. ysabel_lopez@hotmail.com

Investigacion Clinica
|August 4, 2007
PubMed

To better understand the role of the hemostatic mechanism in preeclampsia, placental extracts obtained from 26 normal pregnant women (NP) and 12 patients with severe pre-eclampsia (SPE) were analyzed to determine thrombomodulin (TM), tissue factor (TF), tissue-type plasminogen activator (tPA), plasminogen activator inhibitor (PAI) 1 and 2, and TF pathway inhibitor (TFPI). The results showed similar concentrations of TF, TM and PAI-2 in both groups, while tPA increased no significantly and TFPI and PAI-1 increased significantly in SPE placentas.

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