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Mobile aortic plaques are a cause of multiple brain infarcts seen on diffusion-weighted imaging

Yuji Ueno1, Kazumi Kimura, Yasuyuki Iguchi

  • 1Stroke Center, Department of Stroke Medicine, Kawasaki Medical School, Okayama, Japan. yuji-u@med.juntendo.ac.jp

Stroke
|August 4, 2007
PubMed

Insights

Mobile aortic plaques (MAPs) are an uncommon but significant cause of acute ischemic stroke, often leading to multiple brain infarcts. Identifying MAPs is crucial for understanding stroke etiology and patient characteristics.

Area of Science:

  • Cardiology
  • Neurology
  • Vascular Medicine

Background:

  • Multiple brain infarcts are common in cardioembolic stroke.
  • Mobile aortic plaques (MAPs) are emerging as potential embolic sources.
  • Clinical characteristics of patients with MAPs remain unclear.

Purpose of the Study:

  • To investigate the clinical characteristics of patients with acute ischemic stroke and MAPs.
  • To assess the association between MAPs and diffusion-weighted imaging findings.

Main Methods:

  • Prospective study of acute ischemic stroke patients undergoing transesophageal echocardiography.
  • Classification into groups based on aortic plaque size and mobility (MAPs).
  • Analysis of diffusion-weighted imaging for lesion distribution (single, multiple in single territory, multiple in multiple territories).

Main Results:

  • MAPs were identified in 7% of enrolled patients.
  • Patients with MAPs were older, more frequently male, and had higher rates of coronary artery disease and cerebral arterial stenoses.
  • MAPs were significantly associated with multiple lesions in multiple vascular territories on diffusion-weighted imaging.

Conclusions:

  • Mobile aortic plaques are not rare in acute ischemic stroke patients.
  • MAPs are a significant cause of multiple brain infarcts, particularly in multiple vascular territories.
Abstract

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