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Published on: September 11, 2013
Retinal detachment and prophylaxis in type 1 Stickler syndrome
Alan Ang1, Arabella V Poulson, Sandy F Goodburn
1Vitreoretinal Service, Addenbrooke's Hospital, Cambridge, United Kingdom.
Ophthalmology
|August 7, 2007
Summary
Prophylactic cryotherapy significantly lowers retinal detachment (RD) risk in type 1 Stickler syndrome patients. This treatment also eliminated bilateral detachments in the study cohort.
Area of Science:
- Ophthalmology
- Genetics
- Retinal Diseases
Background:
- Type 1 Stickler syndrome is a genetic disorder associated with an increased risk of retinal detachment.
- Giant retinal tears are a common complication, potentially leading to severe vision loss.
Purpose of the Study:
- To determine the prevalence of retinal detachment (RD) in patients with type 1 Stickler syndrome.
- To evaluate the effectiveness of prophylactic cryotherapy in preventing RD from giant retinal tears in this population.
Main Methods:
- Retrospective analysis of 204 patients with type 1 Stickler syndrome.
- Patients were categorized into three groups: no prophylaxis, bilateral prophylactic cryotherapy, and unilateral prophylaxis in the fellow eye after RD in the other.
Main Results:
- Untreated patients (n=111) had a 73% RD rate, with 48% bilateral.
- Patients receiving bilateral prophylactic cryotherapy (n=62) had an 8% failure rate, with no bilateral detachments.
- Prophylaxis in treated patients showed a significantly lower RD prevalence compared to untreated patients (P<0.001).
Conclusions:
- Prophylactic cryotherapy is highly effective in reducing the incidence of retinal detachment in type 1 Stickler syndrome.
- This prophylactic measure successfully eliminated the occurrence of bilateral detachments in the studied cohort.
