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Updated: Jul 13, 2026
12:23
Granulocyte-dependent Autoantibody-induced Skin Blistering
Published on: October 12, 2012
Intertriginous bullous morphea: A clue for the pathogenesis?
Mukaddes Kavala1, Ilkin Zindanci, Cuyan Demirkesen
1Department of Dermatology, Goztepe Training and Research Hospital, Istanbul, Turkey.
Indian Journal of Dermatology, Venereology and Leprology
|August 7, 2007
Summary
Bullous morphea, a rare skin condition, presents with blisters on hardened plaques. Lymphatic obstruction is the likely cause, differentiating it from similar conditions like lichen sclerosus et atrophicus.
Area of Science:
- Dermatology
- Pathology
Background:
- Morphea is a rare connective tissue disease characterized by localized scleroderma.
- Bullae formation in morphea lesions is uncommon and multifactorial.
Observation:
- A 69-year-old woman with a history of generalized morphea developed pruritic bullae.
- Lesions included erythematous erosions, hemorrhagic vesicles, and eroded bullae on indurated, shiny plaques.
Findings:
- Skin biopsy showed papillary dermal edema leading to bulla formation and thickened collagen fibers.
- Direct immunofluorescence was negative, aiding in diagnosis.
Implications:
- Bullous morphea requires careful clinical and histological evaluation to distinguish it from other blistering disorders.
- Understanding the pathogenesis of bullae in morphea is crucial for effective management.
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