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Real-World Predictors of Relapse-Free Duration After Narrowband UVB in Pediatric Psoriasis: A Multicenter Study

Berna Solak1, Burhan Engin2, Zeynep Güngör3

  • 1Department of Dermatology, Faculty of Medicine, Sakarya University, Sakarya, Türkiye.

Photodermatology, Photoimmunology & Photomedicine
|February 12, 2026
PubMed

Insights

Narrowband ultraviolet B (NB-UVB) phototherapy is effective for pediatric psoriasis, but relapses are common. Topical corticosteroid use may prolong remission, while nail involvement indicates a higher risk of recurrence.

Area of Science:

  • Dermatology
  • Phototherapy
  • Pediatric Medicine

Background:

  • Narrowband ultraviolet B (NB-UVB) phototherapy is a recognized treatment for pediatric psoriasis, offering safety and efficacy.
  • However, a significant challenge remains the high rate of relapse following treatment, with limited data on factors influencing remission duration in children.

Purpose of the Study:

  • To assess treatment outcomes, relapse patterns, and predictors of sustained remission in pediatric psoriasis patients undergoing NB-UVB phototherapy.
  • Specifically investigate the impact of concurrent topical corticosteroid and calcipotriol use, alongside clinical indicators like nail involvement.

Main Methods:

  • A multicenter retrospective study involving 114 pediatric psoriasis patients treated with NB-UVB across six Turkish dermatology centers.
  • Treatment response was defined as achieving at least 75% improvement in the Psoriasis Area and Severity Index (PASI75).
  • Relapse was identified as a significant recurrence within six months post-treatment, necessitating further intervention.

Main Results:

  • A majority of patients (65.8%) achieved PASI75, with 42.1% reaching PASI90. Responders received higher cumulative NB-UVB doses and more treatment sessions.
  • Relapse occurred in 24.0% of responders within six months. Concomitant topical corticosteroid use was linked to longer relapse-free duration (p=0.001), whereas nail involvement predicted shorter remission (p=0.002).
  • Topical calcipotriol and disease subtype did not significantly predict relapse. NB-UVB exhibited a favorable safety profile, with mild erythema and pruritus being the most common side effects.

Conclusions:

  • NB-UVB phototherapy demonstrates high efficacy and a good safety profile for pediatric psoriasis.
  • Concomitant topical corticosteroid use may extend remission periods. Nail involvement serves as a crucial indicator for increased relapse risk, warranting closer patient monitoring and tailored maintenance strategies.
Abstract

Keywords:
nail involvementnarrowband UVBpediatric psoriasisphototherapyrelapsetopical corticosteroids

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