A Real-World Study of Polynucleotides HPT for Treating Periorbital Hyperpigmentation

Area of Science:

• Aesthetic medicine
• Dermatology
• Regenerative medicine

Background:

• Periorbital hyperpigmentation (dark circles) results from factors like aging, sun exposure, and hormonal changes.
• Current treatments for dark circles have limitations in addressing underlying causes.

Purpose of the Study:

• To evaluate the efficacy of intradermal Polynucleotides High Purification Technology (PN HPT) injections for treating dark circles.
• To assess both immediate volume enhancement and long-term skin restructuring effects of PN HPT.

Main Methods:

• An open-label, multinational observational study involving 61 subjects with dark circles.
• PN HPT hydrogel was administered via needle or cannula in three sessions.
• Digital analysis of photographs and subject/specialist assessments were used to evaluate outcomes.

Main Results:

• Significant reduction in periorbital hyperpigmentation was observed (p <0.001), particularly in subjects treated with needles for the structural subtype.
• Progressive improvements in skin quality were noted at one and three months post-treatment.
• Both specialists and subjects reported enhanced skin quality and reduced dark circles.

Conclusions:

• Low-concentration PN HPT offers a dual approach: immediate volume correction and long-term connective tissue restructuring.
• PN HPT may be a viable option for improving the appearance of dark circles and overall quality of life.