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Updated: Jan 23, 2026
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Author Spotlight: Advancing Facial Rejuvenation Therapy with Post-Laser Salicylic Acid Application
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Global Recommendations for Facial Rejuvenation Using a Hyaluronic Acid and Calcium Hydroxyapatite Hybrid Injectable.
Maurizio Cavallini1, Andre Braz2, Daniela Greiner-Krüger3
1Department of Operative Unit, Dermatology and Dermatosurgery, Centro Diagnostic Italiano Hospital, Milan, Italy.
Journal of Cosmetic Dermatology
|January 22, 2026
Summary
This study provides expert recommendations for using hybrid injectable HA-CaHA (hyaluronic acid-calcium hydroxyapatite) for skin rejuvenation. These guidelines ensure safe and effective application for improved skin elasticity and collagenesis.
Area of Science:
- Aesthetic medicine
- Dermatology
- Cosmetic surgery
Background:
- Hybrid injectable HA-CaHA combines hyaluronic acid (HA) gel with calcium hydroxyapatite (CaHA) microspheres.
- This formulation aims to enhance skin elasticity, hydration, and stimulate neocollagenesis.
- Current clinical practice guidelines for HA-CaHA are limited.
Purpose of the Study:
- To establish global recommendations for the safe and effective injection of HA-CaHA.
- To guide practitioners in patient selection, technique, and post-treatment care.
Main Methods:
- An international expert panel of eight consultants convened to develop best-practice recommendations.
- Discussions covered patient selection, skin laxity assessment, injection techniques, retreatment, combination therapies, and safety.
Main Results:
- HA-CaHA is recommended for structural support and soft tissue repositioning in cases of skin laxity, sagginess, and mild to moderate volume loss.
- Injection techniques emphasize using cannulas, targeting lateral facial areas along ligament lines, and small volumes.
- Retreatment is advised only for recurrent mild to moderate laxity.
Conclusions:
- Expert recommendations confirm the safe and effective use of HA-CaHA for improving soft tissue quality.
- Adherence to these guidelines can optimize patient outcomes and minimize risks.
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