Clinical Outcomes of an Innovative Poly-L-Lactic Acid (LASYNPRO) in Facial Rejuvenation: Prospective, Multicenter...

Area of Science:

• Dermatology
• Aesthetic Medicine
• Biomaterials

Background:

• Facial aging involves wrinkles and volume loss.
• Poly-L-lactic acid (PLLA) is a collagen stimulator used in aesthetic treatments.
• PLLA-LASYNPRO is a specific formulation for facial rejuvenation.

Purpose of the Study:

• To assess the clinical efficacy, patient satisfaction, safety, and biological effects of PLLA-LASYNPRO over a 6-month period.
• Evaluate improvements in facial wrinkles and midface volume.
• Investigate the treatment's impact on collagen production and tissue properties.

Main Methods:

• Prospective, multicenter study involving patients treated with PLLA-LASYNPRO.
• Primary endpoint: Wrinkle Severity Rating Scale (WSRS) reduction of at least 1 point.
• Secondary endpoints: Midface Volume Deficit Scale (MFVDS) reduction, patient satisfaction (GAIS), biological changes (ultrasound, elastography, P1CP levels), and adverse events (AEs).

Main Results:

• Significant improvements in WSRS and MFVDS scores were observed, with success rates increasing over 6 months.
• High patient satisfaction reported, with 65.6% rating results as "Much Better" or "Better" at 6 months.
• Ultrasound and elastography confirmed increased tissue density and neocollagenesis; serum P1CP levels significantly increased, indicating collagen stimulation. AEs were mild and self-resolving.

Conclusions:

• PLLA-LASYNPRO effectively treats facial wrinkles and volume loss, leading to sustained aesthetic improvements.
• The treatment is associated with high patient satisfaction and objective biological evidence of collagenesis.
• PLLA-LASYNPRO exhibits an excellent safety profile, supporting its use in aesthetic practice. Further large-scale trials are recommended.