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An Evaluation of VYC-17.5L for Forehead Contouring: A Prospective, Open-Label, Post-Marketing Study
Sofia Ruiz Del Cueto1, Fernando Urdiales Galvez2, Alessandro Gritti3
1Clínica Mira and Cueto, Madrid, Spain.
Journal of Cosmetic Dermatology
|March 3, 2025
Summary
This study shows that VYC-17.5L, a hyaluronic acid (HA) filler, effectively improves forehead contouring. The injectable filler was well-tolerated, with high patient satisfaction and sustained results up to 12 months.
Area of Science:
- Dermatology
- Aesthetic Medicine
- Injectable Fillers
Background:
- Forehead contouring is a common aesthetic procedure.
- Injectable hyaluronic acid (HA) fillers are used for skin depressions.
- VYC-17.5L is an HA filler with lidocaine previously studied for other facial areas.
Purpose of the Study:
- To evaluate the effectiveness and safety of VYC-17.5L for forehead contouring.
- To assess patient and investigator satisfaction with forehead contour improvement.
- To document adverse events associated with VYC-17.5L in the forehead.
Main Methods:
- A prospective, open-label, post-marketing study was conducted in France.
- Eighty adult participants received VYC-17.5L for forehead contouring.
- Effectiveness was measured using the Global Aesthetic Improvement Scale (GAIS) and FACE-Q, with safety assessments for injection site reactions and adverse device effects.
Main Results:
- 97.5% of participants achieved "improved" or "much improved" forehead contour per investigator GAIS at 1 month.
- Participant-rated GAIS and FACE-Q scores showed significant improvement (p < 0.0001) and were sustained for 12 months.
- Most injection site reactions were mild/moderate and resolved within a week; pain was the most common adverse device effect, resolving within 15 days.
Conclusions:
- VYC-17.5L is an effective and well-tolerated injectable filler for forehead contouring.
- The treatment demonstrated high patient satisfaction and sustained aesthetic improvement.
- VYC-17.5L offers a safe option for addressing forehead skin depressions and irregularities.
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