Related Experiment Video

Updated: Jan 31, 2026

The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis
11:39

The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis

Published on: July 11, 2013

39.5K

Clinical and Demographic Characteristics of Pediatric Patients With Psoriasis: Age-Related Variations and Remission

Burhan Engin1, Yusuf Demir1, Gurbuz Yildirim1

  • 1Department of Dermatology, Cerrahpasa Faculty of Medicine, Istanbul University-Cerrahpasa, Istanbul, Turkey.

Pediatric Dermatology
|January 29, 2026
PubMed

Insights

Pediatric psoriasis presentation and remission vary by age. Older children with chronic plaque psoriasis, higher PASI scores, and nail involvement experience longer remission times, suggesting early systemic therapy for high-risk cases.

Area of Science:

  • Dermatology
  • Pediatric Medicine
  • Clinical Research

Background:

  • Psoriasis in children presents unique challenges.
  • Understanding age-related differences in pediatric psoriasis is crucial for effective management.
  • Previous research has not fully elucidated predictors of remission in pediatric psoriasis across different age groups.

Purpose of the Study:

  • To investigate age-related variations in the clinical presentation of pediatric psoriasis.
  • To identify key predictors of remission time in pediatric psoriasis patients.
  • To inform early treatment strategies for high-risk pediatric psoriasis cases.

Main Methods:

  • Retrospective analysis of 110 pediatric patients diagnosed with psoriasis.
  • Evaluation of clinical presentation, including psoriasis type and morphology.
  • Assessment of factors influencing time to remission, such as age, baseline severity (PASSI scores), and treatment modalities.

Main Results:

  • Chronic plaque psoriasis prevalence increased with age, while guttate psoriasis was more common in younger children.
  • Median time to remission significantly increased with patient age.
  • Older age (≥11 years), chronic plaque morphology, higher baseline PASSI scores (≥10), and nail involvement independently predicted longer remission times.
  • Biologic therapy and methotrexate were associated with shorter remission times.

Conclusions:

  • Pediatric psoriasis exhibits significant age-related clinical heterogeneity.
  • Age, disease morphology, severity, and specific clinical features are critical predictors of remission duration.
  • Early identification and systemic therapy are recommended for high-risk pediatric psoriasis patients to improve outcomes.

More Related Videos

Author Spotlight: Self-Assessment Protocol for Predicting Psoriatic Arthritis in Psoriasis Patients02:28

Author Spotlight: Self-Assessment Protocol for Predicting Psoriatic Arthritis in Psoriasis Patients

Published on: March 1, 2024

933
Author Spotlight: Understanding Age-Related Macular Degeneration Pathophysiology with QAF Workflow08:54

Author Spotlight: Understanding Age-Related Macular Degeneration Pathophysiology with QAF Workflow

Published on: May 26, 2023

2.1K

Related Concept Videos

Pharmacokinetics in Pediatric Patients: Drug Excretion01:26

Pharmacokinetics in Pediatric Patients: Drug Excretion

In pediatric medicine, understanding the renal function and drug elimination nuances is crucial for administering safe and effective treatments. Newborns, in particular, display markedly slower renal functions than adults, profoundly affecting how drugs are cleared from their bodies. This slower drug clearance requires clinicians to extend the dosing intervals for many medications to prevent drug accumulation and toxicity while ensuring therapeutic efficacy.One key area where these adjustments...
259
Pharmacokinetics in Pediatric Patients: Drug Distribution01:17

Pharmacokinetics in Pediatric Patients: Drug Distribution

Drug distribution in the pediatric population exhibits unique challenges and considerations due to the physiological differences between children, particularly neonates and infants, and adults. A crucial aspect of pediatric pharmacology is understanding how these differences impact the pharmacokinetics of various drugs, necessitating age-specific dosing strategies to ensure efficacy and safety.Neonates and infants have a higher total body water content, ~75%–90% of their body weight,...
304
Pharmacokinetics in Pediatric Patients: Drug Metabolism01:24

Pharmacokinetics in Pediatric Patients: Drug Metabolism

In pediatric care, understanding the nuances of hepatic drug metabolism is crucial, as it significantly differs from that of adults. This divergence is primarily due to the developmental stage of drug-metabolizing enzymes, which affects how medications are processed in the body. In neonates, for instance, the activity of Phase I enzymes—critical for the initial breakdown of drugs—is markedly reduced, functioning at just 20–40% of the levels seen in adults. This reduction poses...
223
Pharmacokinetics in Pediatric Patients: Overview and Drug Absorption01:23

Pharmacokinetics in Pediatric Patients: Overview and Drug Absorption

Understanding the physiological differences in the pediatric population is crucial for effective pharmacotherapy. Neonates, infants, and children exhibit significant variations in gastric pH, gastric emptying time, intestinal transit time, and biliary function. These variations profoundly affect oral drug absorption, necessitating a nuanced approach to pediatric dosing.Neonates present with a unique physiological profile, having a gastric pH greater than 4 and faster and more irregular gastric...
292
Pharmacodynamics in Geriatric Patients: Effects of Age01:27

Pharmacodynamics in Geriatric Patients: Effects of Age

Age-related pharmacokinetic changes are extensively documented, but understanding age-related pharmacodynamic alterations is relatively limited. This knowledge gap can be partly attributed to the complexity of developing appropriate measures of drug responses compared to bioanalytical methods for determining drug concentrations.Most information regarding age-related differences in human pharmacodynamics originates from cross-sectional studies. However, these studies assume that observed mean...
235
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Absorption01:22

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Absorption

As individuals age, their body's physiology evolves, affecting drug pharmacokinetics. The most apparent changes occur in the gastrointestinal tract, where an increase in gastric pH, a delay in gastric emptying, and a reduction in gastrointestinal motility are observed. Remarkably, these changes do not substantially modify the absorption of orally administered drugs, particularly those absorbed via passive diffusion.Transdermal drug delivery emerges as a highly viable method for older adults due...
701