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Is there an oxidative stress in children with Helicobacter pylori infection?

Duran Arslan1, Kader Kose, Tahir E Patiroglu

  • 1Department of Pediatric Gastroenterology, Faculty of Medicine, Erciyes University, Talas Yolu, 38039, Kayseri, Turkey. duran@erciyes.edu.tr

Saudi Medical Journal
|August 7, 2007
PubMed

Insights

Helicobacter pylori (HP) infection in children increases oxidative stress, specifically malondialdehyde (MDA) in gastric tissue, contributing to tissue damage. Antioxidant enzyme superoxide dismutase (SOD) levels did not differ significantly between infected and non-infected children.

Area of Science:

  • Pediatric Gastroenterology
  • Oxidative Stress Research
  • Microbiology

Background:

  • Helicobacter pylori (HP) infection is prevalent in children globally.
  • HP infection is associated with gastrointestinal inflammation and tissue damage.
  • The role of oxidative stress in HP-related pediatric gastrointestinal pathology requires further elucidation.

Purpose of the Study:

  • To evaluate oxidative stress markers in children with HP infection.
  • To examine the relationship between oxidative stress and inflammatory parameters in pediatric HP infection.
  • To assess the impact of HP eradication therapy on oxidative stress.

Main Methods:

  • A cohort of 39 children undergoing upper gastrointestinal endoscopy were analyzed.
  • Malondialdehyde (MDA) levels and superoxide dismutase (SOD) activity were measured in gastric tissue and erythrocytes.
  • HP infection was confirmed histologically.

Main Results:

  • HP-positive children exhibited elevated MDA levels in gastric tissue, indicating increased lipid peroxidation.
  • No significant differences in MDA levels were found in erythrocytes between HP-positive and HP-negative children.
  • SOD activity in gastric tissue and erythrocytes did not differ between groups; however, tissue SOD activity increased post-treatment.

Conclusions:

  • Oxidative stress, evidenced by elevated MDA, plays a role in gastric tissue damage associated with HP infection in children.
  • Antioxidant enzyme SOD levels were not significantly altered by HP infection itself, but showed a trend towards increase after treatment.
  • Further research is needed to fully understand the complex interplay between HP infection, oxidative stress, and gastrointestinal pathology in pediatric populations.
Abstract

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