Related Experiment Video

Updated: Jul 13, 2026

Implantation of Fibrin Gel on Mouse Lung to Study Lung-specific Angiogenesis
07:52

Implantation of Fibrin Gel on Mouse Lung to Study Lung-specific Angiogenesis

Published on: December 21, 2014

Fumagillin: an anti-infective as a parent molecule for novel angiogenesis inhibitors

Benjamin Lefkove1, Baskaran Govindarajan, Jack L Arbiser

  • 1Department of Dermatology, Emory University School of Medicine, Atlanta, GA 30322, USA. benjaminlefkove@hotmail.com

Expert Review of Anti-Infective Therapy
|August 7, 2007
PubMed

Insights

Fumagillin, an anti-infective from Aspergillus fumigatus, shows high efficacy against microsporidial infections, particularly in HIV-positive patients. Research into novel analogs suggests a promising revival for its anti-infective and antiangiogenic applications.

Area of Science:

  • Microbiology
  • Pharmacology
  • Medicinal Chemistry

Background:

  • Fumagillin, isolated from Aspergillus fumigatus, is a potent amebicide and anti-infective agent.
  • Despite its efficacy, fumagillin's systemic use is not approved in the USA due to side effects.
  • It demonstrates high efficacy in treating microsporidial infections in HIV-positive individuals.

Purpose of the Study:

  • To review the anti-infective and antiangiogenic properties of fumagillin.
  • To highlight the potential of novel fumagillin analogs in drug development.
  • To discuss the revival of fumagillin as a therapeutic agent.

Main Methods:

  • Literature review of fumagillin's properties and analog synthesis.
  • Analysis of efficacy data for microsporidial infections.
  • Evaluation of antiangiogenic potential.

Main Results:

  • Fumagillin exhibits significant anti-infective activity, especially against microsporidia.
  • Novel analogs are being synthesized, showing promise for improved therapeutic profiles.
  • The compound possesses notable antiangiogenic properties.

Conclusions:

  • Fumagillin remains a compound of interest for its anti-infective capabilities.
  • Ongoing research into fumagillin analogs suggests potential for new therapeutic applications.
  • Fumagillin is a promising candidate for both anti-infective and antiangiogenic therapies.

More Related Videos

Automated Preparation of [68Ga]Ga-3BP-3940 on a Synthesis Module for PET Imaging of the Tumor Microenvironment10:33

Automated Preparation of [68Ga]Ga-3BP-3940 on a Synthesis Module for PET Imaging of the Tumor Microenvironment

Published on: April 25, 2025

Rat Mesentery Angiogenesis Assay18:30

Rat Mesentery Angiogenesis Assay

Published on: June 18, 2011

Related Concept Videos

Mechanism of Angiogenesis01:10

Mechanism of Angiogenesis

Blood vessel formation starts early during embryonic development, around day 7. In the extraembryonic yolk sac, mesodermal precursor cells called hemangioblast proliferate and differentiate into angioblast. Angioblasts express vascular endothelial growth factor receptor 2 or VEGFR2, which binds VEGF-A, a proangiogenic factor, guiding blood vessel formation. VEGF signaling promotes angioblasts to form a blood island in the developing embryo. Angioblasts further differentiate, giving rise to...
Antifungal Agents01:15

Antifungal Agents

Amphotericin B is a broad-spectrum antifungal agent that exploits structural differences between fungal and mammalian cell membranes. Its amphipathic structure—featuring a hydrophobic polyene-lactone ring and a hydrophilic region containing mycosamine and carboxylic acid groups—enables selective binding to ergosterol, a sterol predominantly found in fungal plasma membranes. This selective interaction underlies the drug’s antifungal activity, although weak binding to cholesterol contributes to...
Inhibitors of Bacterial Protein Synthesis01:25

Inhibitors of Bacterial Protein Synthesis

Aminoglycosides constitute a highly potent class of bactericidal antibiotics that exert their antimicrobial effects by targeting the bacterial ribosome, specifically disrupting protein synthesis. These polycationic molecules consist of amino-modified sugars linked via glycosidic bonds to an aminocyclitol core such as 2-deoxystreptamine or streptamine. Their strong positive charges facilitate tight binding to the negatively charged phosphate backbone of ribosomal RNA (rRNA), primarily at the 16S...
Inhibitors of Gram-positive Cell Wall Synthesis01:23

Inhibitors of Gram-positive Cell Wall Synthesis

Bacterial cell walls are typically rigid structures composed mainly of peptidoglycan, a mesh-like polymer that provides mechanical strength and maintains cell shape. The synthesis of peptidoglycan is a crucial process in bacterial growth and serves as a primary target for many antibiotics.Mechanism of Action of Beta-Lactam AntibioticsBeta-lactam antibiotics, such as penicillin, inhibit peptidoglycan synthesis in actively growing cells. These antibiotics share a characteristic four-membered...
Immunoglobulin-like Cell Adhesion Molecules01:31

Immunoglobulin-like Cell Adhesion Molecules

Immunoglobulin-like cell adhesion molecules or Ig-CAMs are a versatile group of cell surface glycoproteins belonging to the immunoglobulin protein superfamily. Ig-CAMs possess the characteristic immunoglobulin protein domains and other domains such as the fibronectin type III domain. The Ig domains are glycosylated to varying degrees in different Ig-CAMs.
Ig-CAMs exhibit either homophilic binding (to other Ig-CAMs) or heterophilic binding (to other ligands such as integrins). While most Ig-CAMs...
Antimicrobial Proteins01:23

Antimicrobial Proteins

Antimicrobial proteins are important components of the immune system. They aid the body in combating pathogens by either killing them directly or hindering their replication processes. Four main types of antimicrobial substances are interferons, the complement system, iron-binding proteins, and antimicrobial proteins.
Interferons
Interferons (IFNs) are proteins produced by lymphocytes, macrophages, and fibroblasts infected with viruses. While IFNs cannot prevent viruses from entering and...