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Updated: Jul 28, 2026

Colon Ascendens Stent Peritonitis (CASP) - a Standardized Model for Polymicrobial Abdominal Sepsis
Published on: December 18, 2010
[Immune shifts and their correction in the extremely severe course of diffuse suppurative peritonitis in children]
Insights
Severe peritonitis significantly impairs immune function, decreasing key components like phagocytosis and lymphocytes. Early transfusion of irradiated autologous blood can help normalize immune status and improve patient recovery.
Area of Science:
- Immunology
- Critical Care Medicine
- Surgical Infections
Abstract:
Clinical and immunological studies of 65 patients with extremely severe disseminated suppurative peritonitis have revealed profound disturbances in their immune status. A considerable (2.5-3-fold) decrease in phagocytosis and complement activity, a drastic drop in T-, B-lymphocyte and T-helper content and a depression in T-lymphocyte functional activity have been observed. All this was accompanied by the activation of allergic and autoimmune reactions. Single transfusion of extracorporally X-ray-irradiated autoblood (5-7% of circulating blood volume) promoted an earlier normalization of the patients' critical condition and a prompt correction of the immune shifts.
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