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Updated: Jul 13, 2026

A Simple Bioassay for the Evaluation of Vascular Endothelial Growth Factors
09:04

A Simple Bioassay for the Evaluation of Vascular Endothelial Growth Factors

Published on: March 15, 2016

The direct effects of anti-vascular endothelial growth factor therapy on tumor cells

Christian Moser1, Sven A Lang, Oliver Stoeltzing

  • 1Departments of Surgery and Surgical Oncology, University of Regensburg Medical Center, Germany.

Clinical Colorectal Cancer
|August 8, 2007
PubMed

Insights

Vascular Endothelial Growth Factor Receptors (VEGFRs) are crucial for tumor growth and angiogenesis. This review explores VEGFRs

Area of Science:

  • Oncology
  • Molecular Biology
  • Cell Biology

Background:

  • Vascular Endothelial Growth Factor (VEGF) family members are key regulators of tumor angiogenesis.
  • VEGF functions are mediated by interactions between ligands, high-affinity tyrosine kinase receptors (VEGFRs), and neuropilin co-receptors.
  • VEGFRs are increasingly recognized for expression and function on non-endothelial cells, including tumor cells.

Purpose of the Study:

  • To review the effects and interactions of VEGFRs.
  • To examine the expression and function of VEGFRs on tumor cells.
  • To discuss the impact of anti-VEGF therapy on tumor cells.

Main Methods:

  • Literature review of studies on VEGFRs.
  • Analysis of evidence for VEGFR expression and function on tumor cells.
  • Evaluation of anti-VEGF therapy effects on tumor cells.

Main Results:

  • VEGFRs play complex roles in the tumor microenvironment beyond angiogenesis.
  • VEGFRs are expressed and functional on various tumor cells.
  • Targeting VEGFRs offers potential for refined anti-cancer strategies.

Conclusions:

  • Understanding VEGFRs on tumor cells is vital for cancer therapy.
  • VEGFRs represent a promising target for novel antineoplastic regimens.
  • Further research into VEGFR signaling in tumors can optimize anti-VEGF treatments.

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