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Updated: Jul 13, 2026

Millisecond Hydrogen/Deuterium-Exchange Mass Spectrometry for the Study of Alpha-Synuclein Structural Dynamics Under Physiological Conditions
08:40

Millisecond Hydrogen/Deuterium-Exchange Mass Spectrometry for the Study of Alpha-Synuclein Structural Dynamics Under Physiological Conditions

Published on: June 23, 2022

Residual structure, backbone dynamics, and interactions within the synuclein family

Yoon-Hui Sung1, David Eliezer

  • 1Department of Biochemistry and Program in Structural Biology, Weill Cornell Medical College, 1300 York Avenue, New York, NY 10021, USA.

Journal of Molecular Biology
|August 8, 2007
PubMed
Summary

Alpha-synuclein is linked to Parkinson's disease, while beta and gamma-synuclein are not. This study compares their free-state structures to understand why alpha-synuclein aggregates more readily, contributing to Parkinson's disease.

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