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Related Experiment Video

Updated: Jul 13, 2026

Developing Neuroimaging Phenotypes of the Default Mode Network in PTSD: Integrating the Resting State, Working Memory, and Structural Connectivity

Developing Neuroimaging Phenotypes of the Default Mode Network in PTSD: Integrating the Resting State, Working Memory, and Structural Connectivity

Published on: July 1, 2014

Does the brain have a baseline? Why we should be resisting a rest.

Alexa M Morcom¹, Paul C Fletcher

¹Brain Mapping Unit, Department of Psychiatry, University of Cambridge, UK. amm96@cam.ac.uk

|August 8, 2007

Summary

The brain's "default mode" network is highly active during rest, but this study questions its status as an absolute baseline. Researchers challenge the utility of resting-state brain activity for understanding cognitive function.

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Area of Science:

Neuroscience
Cognitive Neuroscience
Brain Imaging

Background:

The concept of a brain default mode network (DMN) has gained traction due to consistent high activity in specific regions during rest.
This resting state is associated with significant energy consumption and a regulated balance of metabolic demand and blood supply.

Purpose of the Study:

To critically examine the assumptions underpinning the significance of the brain's default mode.
To question the interpretability and value of studying the resting state in neuroscience.

Main Methods:

Review and critical analysis of existing research on the default mode network.
Conceptual examination of the assumptions in resting-state fMRI studies.

Main Results:

The study challenges the notion that the default mode network represents an absolute baseline of brain function.
It questions the privileged status of resting-state observations for understanding brain activity.

Conclusions:

Observations during rest may not hold a fundamental status for characterizing overall brain functioning.
The utility of resting-state studies across various research domains is questioned, advocating for a re-evaluation of their interpretability.