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Dental pulp lipids from Bos taurus during odontogenesis
A Antonucci1, N Toto, V Di Valerio
1Department of Human Morphology, University of Chieti, Italy.
Archives of Oral Biology
|January 1, 1991
Summary
Lipid profiles in developing dental pulp differ between deciduous and permanent teeth, with notable changes in cholesterol and triglycerides. These shifts are linked to plasma membrane formation and nerve development during tooth maturation.
Area of Science:
- Biochemistry
- Developmental Biology
- Dental Research
Background:
- The dental pulp undergoes significant biochemical changes during development.
- Understanding lipid composition is crucial for comprehending pulp ontogeny and postnatal maturation.
Purpose of the Study:
- To investigate the changes in various lipid classes during the development of human dental pulp.
- To compare lipid profiles between fetal, deciduous, and permanent teeth.
Main Methods:
- Lipid analysis using chromatography.
- Quantification of free cholesterol, esterified cholesterol, triglycerides, phosphatidylcholine, sphingomyelin, phosphatidylserine, and phosphatidylethanolamine.
Main Results:
- Free cholesterol decreased in both deciduous and permanent teeth compared to fetal teeth.
- Esterified cholesterol increased in permanent teeth; triglyceride levels were elevated only in developing permanent teeth.
- Specific phospholipids (phosphatidylcholine, sphingomyelin, phosphatidylserine) were higher in permanent unerupted teeth, while phosphatidylethanolamine levels varied.
Conclusions:
- Lipid composition of dental pulp changes significantly during tooth development.
- These lipid alterations are associated with the formation of plasma membranes and the establishment of innervation.
- The findings provide insights into the molecular processes underlying dental pulp ontogeny.