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Risk factors associated with chronic lung disease in Malaysian very low birthweight infants

S A K M Ameenudeen1, N Y Boo, L G Chan

  • 1Department of Paediatrics, Sarawak General Hospital, Kuching, Sarawak.

The Medical Journal of Malaysia
|August 9, 2007
PubMed

Insights

Lower birth weight, male sex, chorioamnionitis, severe respiratory distress, and patent ductus arteriosus are key risk factors for chronic lung disease (CLD) in Malaysian very low birthweight (VLBW) infants. Identifying these factors aids in early intervention and improved outcomes for VLBW neonates.

Area of Science:

  • Neonatology
  • Pediatric Pulmonology
  • Public Health

Background:

  • Chronic lung disease (CLD) poses a significant challenge in the management of preterm infants.
  • Very low birthweight (VLBW) infants are particularly vulnerable to developing CLD.
  • Understanding risk factors is crucial for targeted interventions in Malaysian VLBW populations.

Purpose of the Study:

  • To identify significant risk factors for CLD development in Malaysian VLBW infants.
  • To provide data for improving clinical management and outcomes for VLBW neonates in Malaysia.

Main Methods:

  • Prospective observational study conducted over 29 months at Sarawak General Hospital.
  • Recruitment of VLBW infants (600g-1500g) admitted to the hospital.
  • Definition of CLD as persistent oxygen need at 36 weeks postmenstrual age; logistic regression analysis for risk factors.

Main Results:

  • 14.8% of 224 VLBW infants developed CLD.
  • Significant risk factors identified: lower birth weight, male sex, chorioamnionitis, severe respiratory distress syndrome (RDS) grades 3-4, and patent ductus arteriosus (PDA).
  • Adjusted odds ratios indicated substantial increased risk for these factors.

Conclusions:

  • Lower birth weight, male sex, chorioamnionitis, severe RDS, and PDA are significant predictors of CLD in Malaysian VLBW infants.
  • Several identified risk factors are treatable, suggesting potential for preventative strategies.
  • Findings highlight the need for focused care on high-risk VLBW infants in Malaysia.

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