Related Experiment Video

Updated: Dec 10, 2025

Biochemical Measurement of Neonatal Hypoxia
13:13

Biochemical Measurement of Neonatal Hypoxia

Published on: August 24, 2011

14.3K

Haemoglobin Constant Spring (HbA2: c.427T>C) and Haemoglobin Adana (HbA2: c.179G>A) in jaundiced Malaysian term

S Shwe1, N Y Boo, H K Ong

  • 1Universiti Tunku Abdul Rahman (UTAR), Faculty of Medicine and Health Sciences, Kajang, Malaysia. boony@utar.edu.my.

The Malaysian Journal of Pathology
|August 30, 2020
PubMed

Insights

Haemoglobin Constant Spring (Hb CoSp) was detected in 0.27% of jaundiced Malaysian neonates, with both cases linked to significant hyperbilirubinemia. Haemoglobin Adana was not found in this study population.

Area of Science:

  • Medical Genetics
  • Neonatal Medicine
  • Hematology

Background:

  • Haemoglobin Constant Spring (Hb CoSp) and Haemoglobin Adana (Hb Adana) are non-deletion α-thalassemia variants prevalent in Malaysia.
  • These variants can cause structural instability, leading to hemolysis and hyperbilirubinemia in neonates.

Purpose of the Study:

  • To determine the prevalence of Hb CoSp and Hb Adana in Malaysian term neonates with jaundice.
  • To investigate the association between these Hb variants and clinically significant neonatal hyperbilirubinemia (SigNH).

Main Methods:

  • Observational study involving term neonates admitted for phototherapy.
  • DNA extracted from dried blood spots was analyzed using PCR-restriction fragment length polymorphism for Hb CoSp and Hb Adana detection.
  • Positive samples were confirmed by gene sequencing.

Main Results:

  • Out of 1121 neonates, Hb CoSp was detected in two (0.27%) neonates, both of whom had SigNH (0.3%).
  • No cases of Hb Adana variant were identified in the study cohort.

Conclusions:

  • Hb CoSp is a rare variant but may be a risk factor for significant neonatal hyperbilirubinemia.
  • Hb Adana was not detected in this cohort of jaundiced Malaysian neonates.
Abstract

More Related Videos

A Precision Medicine Tool for Measurement and Monitoring of Hemoglobin S in Sickle Cell Disease Patients Receiving Transfusion Therapy07:24

A Precision Medicine Tool for Measurement and Monitoring of Hemoglobin S in Sickle Cell Disease Patients Receiving Transfusion Therapy

1.8K
A Rapid and Chemical-free Hemoglobin Assay with Photothermal Angular Light Scattering05:18

A Rapid and Chemical-free Hemoglobin Assay with Photothermal Angular Light Scattering

Published on: December 7, 2016

10.0K

Related Concept Videos

Hemoglobin01:24

Hemoglobin

Hemoglobin is a globular protein made up of four subunits. Two of these subunits are alpha chains, and the other two are beta chains. Each subunit contains a molecule of heme, which has an iron atom and can bind to oxygen. When an oxygen molecule binds to one heme group, it changes the shape of hemoglobin, making it easier for the other heme groups to bind oxygen as well.
When all four heme groups are bound to oxygen, the resulting molecule is called oxyhemoglobin. As a result, arterial blood...
6.9K
Rh Blood Group01:19

Rh Blood Group

The Rhesus (Rh) antigen is crucial in determining blood groups and ensuring compatibility during blood transfusions.
2.5K
Oxygen Transport in the Blood01:27

Oxygen Transport in the Blood

Hemoglobin (Hb) is a crucial molecule in the human body, consisting of four polypeptide chains, each bound to an iron-containing heme group. This unique structure enables hemoglobin to bind to oxygen, with each molecule capable of combining with four molecules of oxygen, leading to rapid and reversible oxygen loading. When fully loaded with oxygen, it is called oxyhemoglobin, while hemoglobin that has released oxygen is called reduced hemoglobin or deoxyhemoglobin. As hemoglobin binds oxygen,...
5.3K
Blood Transfusion and Agglutination02:45

Blood Transfusion and Agglutination

Blood transfusion is a therapeutic measure to restore the blood volume after extensive blood loss due to an accident or a medical procedure. Blood transfusion involves drawing a certain amount of blood from a suitable donor and infusing it into the recipient.
History
The history of blood transfusion dates back to the 17th century, when early attempts were made in animals. In 1818 James Blundell, a British doctor, performed the first successful human blood transfusion. Later in 1900, Karl...
13.6K
Pharmacokinetics in Pediatric Patients: Drug Metabolism01:24

Pharmacokinetics in Pediatric Patients: Drug Metabolism

In pediatric care, understanding the nuances of hepatic drug metabolism is crucial, as it significantly differs from that of adults. This divergence is primarily due to the developmental stage of drug-metabolizing enzymes, which affects how medications are processed in the body. In neonates, for instance, the activity of Phase I enzymes—critical for the initial breakdown of drugs—is markedly reduced, functioning at just 20–40% of the levels seen in adults. This reduction poses...
108
Changes in Skin Color: Clinical Perspectives01:14

Changes in Skin Color: Clinical Perspectives

The first thing a clinician sees is the skin, so the examination of the skin should be part of any thorough physical examination. Most skin disorders are relatively benign, but a few, including melanomas, can be fatal if untreated. A couple of the more noticeable disorders, albinism and vitiligo, affect the appearance of the skin and its accessory organs.
Albinism
Albinism is a genetic disorder that affects (completely or partially) the coloring of skin, hair, and eyes. The defect is primarily...
3.2K