Related Experiment Video
Updated: Jul 13, 2026
05:13
Preclinical Model of Prenatal Delta-9-Tetrahydrocannabinol Exposure to Assess Its Impact on Neurodevelopmental Outcomes
Published on: February 28, 2025
[Prenatal tolerability evaluation of diclofenac]
Piotr Przybylski1, Joanna Kiś, Franciszek Burdan
1Akademia Medyczna w Lublinie, Pracownia Teratologii Doświadczalnej Katedry i Zakładu Anatomii Prawidłowej Człowieka.
Summary
Diclofenac, a nonsteroidal anti-inflammatory drug, shows no teratogenic effects in animal studies. However, potential fetal side effects like growth retardation warrant careful consideration during pregnancy.
Area of Science:
- Pharmacology
- Reproductive Toxicology
Context:
- Diclofenac is a widely used nonsteroidal anti-inflammatory drug (NSAID).
- Recently classified as an over-the-counter (OTC) medication.
- Concerns exist regarding its reproductive and fetal safety.
Purpose:
- To evaluate the reproductive and teratogenic effects of diclofenac.
- To synthesize findings from animal studies and human reports on diclofenac's fetal impact.
Summary:
- Animal studies indicate diclofenac is not teratogenic.
- Reported adverse fetal effects include intrauterine growth retardation and ductus arteriosus constriction.
- Human data do not establish a link between diclofenac exposure and fetal risk.
Impact:
- Informs clinical practice regarding NSAID use in pregnancy.
- Highlights the importance of risk-benefit assessment for OTC medications.
- Guides future research on NSAID reproductive safety.
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