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Related Experiment Video

Updated: Jul 13, 2026

Tumor Spheroid Fabrication and Encapsulation in Polyethylene Glycol Hydrogels for Studying Spheroid-Matrix Interactions
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Sol-gel-derived spheres for spherical microcavity.

Shuichi Shibata1, Tetsuji Yano, Hiroyo Segawa

  • 1Tokyo Institute of Technology, 2-12-1 Ookayama, Meguro-ku, Tokyo 152-8550, Japan. sshibata@ceram.titech.ac.jp

Accounts of Chemical Research
|August 9, 2007
PubMed
Summary

Researchers fabricated micrometer-sized hybrid material spheres for use as spherical cavity microlasers. These spheres demonstrate potential for enhanced light-material interactions and laser applications.

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Area of Science:

  • Optics and Photonics
  • Materials Science
  • Laser Physics

Background:

  • High quality factor (Q factor) cavities enhance light-material interactions.
  • Micrometer-sized spheres offer potential for high Q factor optical cavities.
  • Organic-inorganic hybrid materials provide tunable optical properties.

Purpose of the Study:

  • Fabricate micrometer-sized spherical particles from organic-inorganic hybrid materials.
  • Investigate the potential of these spheres as spherical cavity microlasers.
  • Explore the effects of doping and coating on optical properties.

Main Methods:

  • Utilized the vibrating orifice technique for sphere fabrication.
  • Prepared nondoped, dye-doped, and rare-earth-metal-ion-doped spheres.

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  • Applied low-index coatings to some spheres for practical applications.
  • Pumped spheres using pulsed and continuous-wave lasers (532 nm and 514 nm).
  • Investigated lasing and resonant light emission via direct pumping and optical waveguide coupling.

    • Main Results:

    • Fabricated high refractive index spheres (n D = 1.72–2.5) and glass spheres (n D = 1.93).
    • Observed emission originating from dopant photoluminescence and matrix Raman scattering.
    • Demonstrated lasing and resonant light emission from the spherical cavities.

    Conclusions:

    • Micrometer-sized organic-inorganic hybrid spheres can function as effective spherical cavity microlasers.
    • The fabrication technique and material composition are suitable for developing advanced optical devices.
    • These findings open avenues for enhanced light-material interaction studies and applications.