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Experimental Endocarditis Model of Methicillin Resistant Staphylococcus aureus (MRSA) in Rat
Published on: June 4, 2012
Unusual cardiac complications of Staphylococcus aureus endocarditis
Chandra Kunavarapu1, Yefin Olkovsky, James C Lafferty
1Department of Cardiology, Medical College of Georgia, Augusta, Georgia 30912, USA. ckunavarapu@mcg.edu
Abstract:
Bacterial endocarditis is a complex disease that is associated with significant morbidity and mortality. Staphylococcus aureus is an organism commonly responsible for acute bacterial infective endocarditis. Patients many times develop an acute fulminant infection resulting in multiple complications, even in the face of adequate therapy. We report an unusual case of S. aureus acute bacterial infective endocarditis in an immunocompromised patient resulting in multiple cardiac complications, including bacterial pericarditis with effusion, mycotic aneurysm of one of the coronary arteries, a valvular vegetation leading to an aneurysmal dilatation at the mitral-aortic junction (intervalvular fibrosa), and a fistulous communication between the left ventricle and left atrium. We present detailed echocardiographic images of these anomalies, which were subsequently confirmed intraoperatively. The patient underwent open heart surgery with pericardial patch repair of the mitral-aortic intervalvular fibrosa aneurysm and fistula.
Insights
Staphylococcus aureus endocarditis can cause severe cardiac issues, even with treatment. This case highlights rare complications like coronary artery aneurysms and left ventricle-left atrium fistulas in an immunocompromised patient.
Area of Science:
- Cardiology
- Infectious Diseases
- Medical Case Reports
Background:
- Bacterial endocarditis, particularly Staphylococcus aureus infective endocarditis, presents significant morbidity and mortality.
- Acute bacterial endocarditis can lead to severe complications despite appropriate medical management.
Observation:
- An immunocompromised patient presented with acute Staphylococcus aureus bacterial endocarditis.
- The patient developed multiple, unusual cardiac complications.
Findings:
- Complications included bacterial pericarditis with effusion, a mycotic coronary artery aneurysm, and valvular vegetation.
- Aneurysmal dilatation at the mitral-aortic junction (intervalvular fibrosa) and a left ventricle-to-left atrium fistula were identified.
- Echocardiography revealed these anomalies, confirmed intraoperatively.
Implications:
- This case underscores the potential for severe and rare cardiac complications in Staphylococcus aureus endocarditis, especially in immunocompromised individuals.
- Surgical intervention, including pericardial patch repair, was necessary for managing these complex cardiac anomalies.
- Highlights the importance of comprehensive diagnostic imaging and timely surgical management in complex endocarditis cases.
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Endocarditis I: Introduction
Endocarditis II: Clinical Features of Infective Endocarditis
Staphylococcal Skin Infections
Rheumatic Heart Disease I: Introduction
Endocarditis IV: Nursing Management
Endocarditis III: Medical Management
