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Related Experiment Video

Updated: Jul 13, 2026

An In Vivo Assessment of Blood-Brain Barrier Disruption in a Rat Model of Ischemic Stroke

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Published on: March 11, 2018

Blood-fluid levels in the brain.

B S Morris¹, A M Nagar, A C Morani

¹Department of Radiology, K E M Hospital, Acharya Dhonde Marg, Parel, Mumbai-400012, India.

The British Journal of Radiology

|August 9, 2007

Summary

Blood-fluid levels in brain cysts appear varied across different causes, including tumors and vascular issues. This finding, not widely documented, offers new insights into intracranial cystic lesions.

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Area of Science:

Neurology
Radiology
Pathology

Background:

Blood-fluid levels in intracranial cystic lesions are an under-documented radiological finding.
Previous literature has not significantly highlighted the varied appearance of these levels across different etiologies.

Purpose of the Study:

To prospectively review and categorize intracranial cystic lesions exhibiting blood-fluid levels.
To analyze the varied appearances of blood-fluid levels in relation to the underlying pathology.

Main Methods:

Prospective review of 17 cases of intracranial cystic lesions over 4 months.
Categorization of lesions based on etiology: primary neoplasms, metastatic deposits, vascular lesions, and traumatic bleeds.

Main Results:

Four types of intracranial cysts with blood-fluid levels were identified.
Examples included primary brain tumors (oligodendroglioma, astrocytoma, schwannoma, Von Hippel-Lindau syndrome), metastases (breast, liver, ovary, lung), vascular causes (infarction, hypertension, anticoagulant therapy), and trauma.
Intracranial cysts within tumors are likely due to blood-brain barrier breakdown, not tumor degeneration.

Conclusions:

Blood-fluid levels in intracranial cystic lesions present with varied appearances depending on the etiology.
The breakdown of the blood-brain barrier is a more probable cause for intracranial cysts within tumors than previously thought.