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Prediabetes in rural and urban children in 3 states in Mexico

Celia Aradillas-García1, Juan M Malacara, Ma Eugenia Garay-Sevilla

  • 1Facultad de Medicina, Universidad Autónoma de San Luis Potosí, San Luis Potosí Mexico.

Journal of the Cardiometabolic Syndrome
|August 9, 2007
PubMed

Insights

In central Mexico, 5.7% of children aged 6-13 had prediabetes, linked to insulin resistance, not obesity. This significant finding highlights geographic and metabolic factors in pediatric prediabetes.

Area of Science:

  • Pediatric Endocrinology
  • Metabolic Health
  • Public Health Research

Background:

  • Prediabetes prevalence and risk factors in children are critical public health concerns globally.
  • Understanding geographic and metabolic associations is key to developing targeted interventions.
  • Central Mexico presents a unique demographic for studying pediatric metabolic health trends.

Purpose of the Study:

  • To determine the frequency, distribution, and associated factors of prediabetes in children from central Mexico.
  • To investigate the relationship between prediabetes, insulin resistance, and lifestyle factors in a pediatric cohort.
  • To compare prediabetes prevalence in rural versus urban settings and across different geographic locations.

Main Methods:

  • Cross-sectional study involving 1238 children aged 6-13 years from San Luis Potosí, León, and Querétaro.
  • Data collection included family history, somatometry, fasting glucose, insulin, and lipid profiles.
  • Homeostasis Model Assessment of Insulin Resistance (HOMA-IR) was calculated to assess insulin resistance.

Main Results:

  • A 5.7% frequency of prediabetes (fasting glucose 100-125 mg/dL) was observed; no type 2 diabetes cases were found.
  • Children with prediabetes exhibited higher HOMA-IR scores and elevated total and HDL cholesterol levels.
  • Prediabetes was more common in León, with similar prevalence in rural and urban children. Insulin resistance affected 24.1% of participants, higher in urban areas and San Luis Potosí.

Conclusions:

  • Prediabetes is a significant issue among children in central Mexico, associated with insulin resistance and geographic location (León).
  • The study found no association between prediabetes and obesity or urban versus rural dwelling.
  • Findings underscore the importance of metabolic screening and tailored public health strategies for pediatric prediabetes in the region.

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