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Related Concept Videos

Cell Migration01:09

Cell Migration

Cell migration, the process by which cells move from one location to another, is essential for the proper development and viability of organisms throughout their life. When cells are not able to migrate properly to their ordained locations, various disorders may occur. For example, disruption in cell migration causes chronic inflammatory diseases such as arthritis.
Cell Migration01:19

Cell Migration

Cell migration is a process by which the cells move from one location to another, playing an essential role in embryological development, repair and regeneration, immune response, and metastasis. Cells migrate in response to chemical or mechanical signals generated by specific organs or tissues. The overall mechanism includes three steps - polarization, protrusion, and release. Polarization involves the formation of a distinct cell front and rear, which determines the direction of movement.
Chemotaxis and Direction of Cell Migration01:21

Chemotaxis and Direction of Cell Migration

Cells can detect chemical cues in their environment and reorganize the cytoskeleton to migrate toward them or away from them. This directional migration, called chemotaxis, is essential during embryogenesis and development, immune response, tissue repair and regeneration, and reproduction. These chemical cues can either attract or repel the cell's movement. For example, axon development is determined by a combination of chemoattractants and chemorepellents that direct the growing axon towards...
Cytoskeletal Coordination in Cell Migration01:32

Cytoskeletal Coordination in Cell Migration

A migrating cell changes its shape during the cyclic events of attachment and detachment from the substratum and repositions the cell organelles correspondingly. These complex events are orchestrated by the dynamic cytoskeletal network comprising actin filaments, intermediate filaments, and microtubules. Cytoskeletal crosstalk — the direct and indirect communication between the different components — is crucial for this coordination. Direct communication involves various linker proteins that...
Cell Polarization by Rho Proteins01:21

Cell Polarization by Rho Proteins

Cell polarity is the asymmetric distribution of cellular and membrane components, making one side of the cell different from the other. This polarity is essential to many processes such as embryogenesis, axon migration, glucose transport across epithelial cells, and directional cell migration. A migrating cell responds to intracellular or extracellular signals via molecular cascades that reorganize the actin cytoskeleton to establish this polarity. In these cells, the Rho family proteins Cdc42,...
Neurotransmitters01:31

Neurotransmitters

Neurotransmitters are essential chemical messengers within the nervous system, facilitating the communication between neurons. These chemical messengers, varying in function and effect, are critical for sustaining various aspects of neurological health and emotional well-being.

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Nucleofection of Rodent Neuroblasts to Study Neuroblast Migration In vitro
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Published on: November 12, 2013

Neurotransmitters regulate cell migration in the telencephalon.

Julian Ik-Tsen Heng1, Gustave Moonen, Laurent Nguyen

  • 1Division of Molecular Neurobiology, National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK.

The European Journal of Neuroscience
|August 10, 2007
PubMed
Summary

Neurotransmitters regulate neuronal migration in the mammalian telencephalon. This review explores how neurotransmitters and their receptors guide developing neurons during CNS formation and in adulthood.

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Area of Science:

  • Neuroscience
  • Developmental Biology
  • Cell Biology

Background:

  • Neuronal migration is crucial for the mammalian telencephalon's complex structure.
  • Neurons migrate radially (glutamatergic) or tangentially (GABAergic).
  • Mechanisms guiding specific neuronal migration remain incompletely understood.

Purpose of the Study:

  • To review the role of neurotransmitters in neuronal migration.
  • To discuss how neurotransmitter receptors influence cell movement.
  • To highlight implications for CNS development and maintenance.

Main Methods:

  • Literature review of studies on neuronal migration.
  • Analysis of research on neurotransmitter signaling in the CNS.
  • Synthesis of findings on receptor-mediated migration.

Main Results:

  • Neurotransmitters, beyond synaptic function, regulate cell migration.
  • Activation of neurotransmitter receptors is key to guiding neurons.
  • This signaling is vital for establishing telencephalic architecture.

Conclusions:

  • Neurotransmitters and their receptors are integral to neuronal migration.
  • These mechanisms are critical during development and in the adult CNS.
  • Further research can elucidate complex molecular machinery involved.