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Updated: Jul 13, 2026
A Murine Model of Stent Implantation in the Carotid Artery for the Study of Restenosis
Published on: May 14, 2013
[Expression of c-myc mRNA on early restenosis after carotid endarterectomy]
Chun-yang Liang1, Ding-biao Zhou, Xin-guang Yu
1Department of Neurosurgery, General Hospital of Chinese PLA, Beijing 100853, China. chunyangliang@sina.com
Objective:
To explore the expression and changes of protooncogene c-myc in early restenosis after carotid endarterectomy (CEA).
Methods:
Using New Zealand Rabbits, carotid atherosclerotic stenosis (CASS) model were created. The expression of c-myc in early restenosis after CEA were detected by quantitative real-time polymerase chain reaction (qRT-PCR).
Results:
In this experiment protooncogene c-myc was analysed at pre-operation, 4 hours and 1 d after CEA by qRT-PCR, and the level of mRNA of c-myc was reached maximum at 4 hours, and decreased following significantly, but still higher than pre-operation.
Conclusions:
The activation of protooncogene c-myc may be generator factor of vascular smooth muscle cell proliferation.
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