Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Muscle Recovery and Fatigue

Muscle Recovery and Fatigue

Muscle fatigue refers to the decline in a muscle's ability to maintain the force of contraction after prolonged activity. It primarily stems from changes within muscle fibers. Even before experiencing muscle fatigue, one may feel tired and have the urge to stop the activity. This response, known as central fatigue, occurs due to changes in the central nervous system, namely the brain and spinal cord. While there is no single mechanism that induces fatigue, it may serve as a protective response...

Fatigue

Fatigue

Fatigue occurs when materials rupture under repeated or fluctuating loads, even at stress levels far below their static breaking strength. It typically results in brittle failure, even for ductile materials. It is a critical consideration in designing machines and structural components subjected to repetitive or varying loads. The nature of these loadings can range from fluctuating loads like unbalanced pump impellers causing vibrations to repeatedly bending a thin steel rod wire back and forth...

Heart Failure VI: Adjunct Therapies

Heart Failure VI: Adjunct Therapies

Additional therapies for treating patients with heart failure (HF) may include procedural interventions, supplemental oxygen, the management of sleep disorders, and nutritional therapy.Procedural InterventionsImplantable Cardioverter-Defibrillator: For patients at risk of life-threatening arrhythmias due to severe left ventricular dysfunction, an Implantable Cardioverter-Defibrillator (ICD) can detect and terminate these arrhythmias, preventing sudden cardiac death and improving survival rates.

Heart Failure VII: Nursing Interventions

Heart Failure VII: Nursing Interventions

The first step in nursing management of a patient with heart failure involves thoroughly assessing the patient's medical history.Subjective Data: Obtain the patient's medical history of coronary artery disease, hypertension, myocardial infarction, and symptoms like dyspnea, orthopnea, and paroxysmal nocturnal dyspnea.Objective Data: Conduct a physical examination to identify findings such as jugular vein distention, pulmonary crackles, tachycardia, murmurs, peripheral edema, and vital signs,...

Increased pulse rate

Increased pulse rate

Tachycardia is a condition marked by an abnormally fast or irregular heart rate, surpassing the typical resting rate. In adults, tachycardia is characterized by a pulse rate ranging from 100 to 180 beats per minute. The increased heart rate can result in inadequate blood flow to various body parts, ultimately diminishing the oxygen supply to organs and tissues.
Many factors can elevate the risk of developing tachycardia. These include advanced age, a family history of arrhythmias, and an...

Cardiomyopathy VI: Nursing Management

Cardiomyopathy VI: Nursing Management

Assessment: Nursing management of patients with cardiomyopathy begins with a thorough assessment of the patient's history, including a family history of cardiomyopathy or sudden cardiac death, personal history of heart disease, hypertension, diabetes, and any alcohol consumption or drug use.During the physical examination, assess vital signs, look for signs of heart failure (such as edema, jugular venous distention, and cyanosis), auscultate for abnormal heart sounds (like murmurs and gallops),...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

High false-positive rate of questionnaire-based restless legs syndrome diagnosis in multiple sclerosis.

Sleep medicine·2015

Same author

Interpreting therapeutic effect in multiple sclerosis via MRI contrast enhancing lesions: now you see them, now you don't.

Journal of neurology·2014

Same author

Impact of sleep disorder treatment on fatigue in multiple sclerosis.

Multiple sclerosis (Houndmills, Basingstoke, England)·2012

Same author

Obstructive sleep apnea is associated with fatigue in multiple sclerosis.

Multiple sclerosis (Houndmills, Basingstoke, England)·2011

Same author

Health care strategies to promote earlier presentation of symptomatic breast cancer: perspectives of women and family physicians.

Current oncology (Toronto, Ont.)·2011

Same author

Pathological changes in horses dying with equine influenza in Australia, 2007.

Australian veterinary journal·2011

Search research articles

Related Experiment Video

Updated: Jul 13, 2026

The Treadmill Fatigue Test: A Simple, High-throughput Assay of Fatigue-like Behavior for the Mouse

The Treadmill Fatigue Test: A Simple, High-throughput Assay of Fatigue-like Behavior for the Mouse

Published on: May 31, 2016

Treating fatigue.

Y Lapierre¹, S Hum

¹Montreal Neurological Hospital/Institute, 3801 University, Montreal, Quebec, Canada H3A 2B4.

International MS Journal

|August 10, 2007

Summary

Multiple Sclerosis (MS) fatigue is a common yet poorly understood symptom. This review highlights research and recommends a multidisciplinary approach, including pharmaceutical and non-pharmaceutical treatments, for managing MS fatigue.

Area of Science:

Neurology
Clinical Medicine
Rehabilitation

Background:

Fatigue is a prevalent and debilitating symptom in Multiple Sclerosis (MS).
A formal definition and clear understanding of MS fatigue's mechanisms and causes remain elusive.
Existing research on MS fatigue is extensive but lacks a unified perspective.

Purpose of the Study:

To review current research on fatigue in Multiple Sclerosis.
To emphasize the need for a standardized definition and understanding of MS fatigue.
To advocate for a comprehensive, multidisciplinary management strategy for patients experiencing MS fatigue.

Main Methods:

Systematic review of existing literature on MS fatigue.
Synthesis of research findings on fatigue mechanisms and causes.

More Related Videos

Evaluating the Role of Mitochondrial Function in Cancer-related Fatigue

Evaluating the Role of Mitochondrial Function in Cancer-related Fatigue

Published on: May 17, 2018

Related Experiment Videos

Last Updated: Jul 13, 2026

The Treadmill Fatigue Test: A Simple, High-throughput Assay of Fatigue-like Behavior for the Mouse

The Treadmill Fatigue Test: A Simple, High-throughput Assay of Fatigue-like Behavior for the Mouse

Published on: May 31, 2016

Evaluating the Role of Mitochondrial Function in Cancer-related Fatigue

Evaluating the Role of Mitochondrial Function in Cancer-related Fatigue

Published on: May 17, 2018

Analysis of current and proposed treatment modalities for MS fatigue.

Main Results:

Fatigue significantly impacts the quality of life and daily functioning of MS patients.
Current understanding of MS fatigue's etiology is incomplete, hindering targeted treatment.
A consensus on fatigue definition and management is lacking within the medical community.

Conclusions:

A multidisciplinary approach is essential for effective MS fatigue management.
Integrating pharmaceutical and non-pharmaceutical interventions offers the most promising strategy.
Further research is needed to elucidate MS fatigue mechanisms and establish a formal definition.