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Updated: Jul 13, 2026
12:37
Pharmacologic Induction of Epidermal Melanin and Protection Against Sunburn in a Humanized Mouse Model
Published on: September 7, 2013
Sun exposure and non-Hodgkin lymphoma: a population-based, case-control study
Lori K Soni1, Lifang Hou, Susan M Gapstur
1Department of Preventive Medicine, Northwestern University Medical School, Chicago, IL, United States.
European Journal of Cancer (Oxford, England : 1990)
|August 10, 2007
Summary
Higher total sun exposure may reduce non-Hodgkin lymphoma (NHL) risk. This association was stronger in farmers and varied by NHL subtype, with vitamin D intake showing no modifying effect.
Area of Science:
- Epidemiology
- Environmental Health
- Oncology
Background:
- Non-Hodgkin lymphoma (NHL) is a heterogeneous group of malignancies.
- The role of environmental factors, such as sun exposure, in NHL development requires further investigation.
Purpose of the Study:
- To examine the association between sun exposure and NHL risk, considering histologic subtypes.
- To determine if vitamin D intake modifies the relationship between sun exposure and NHL risk.
Main Methods:
- Population-based case-control study in Nebraska (1999-2002).
- Data collected via telephone interviews from 387 NHL cases and 535 controls.
- Assessed seasonal and total sun exposure, and vitamin D intake.
Main Results:
- No association found between seasonal sun exposure or vitamin D intake and NHL risk.
- Total hours of sun exposure showed an inverse association with NHL risk (OR=0.7).
- This inverse association was stronger among farmers and linked to specific NHL subtypes (diffuse large B-cell lymphoma, T-cell lymphoma).
Conclusions:
- Total sun exposure appears to be associated with a reduced risk of NHL.
- Vitamin D intake did not modify the sun-NHL association.
- The protective effect of sun exposure may be occupation-dependent and subtype-specific.
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