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Updated: Jul 13, 2026
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A Protocol for Roux-en-Y Gastric Bypass in Rats using Linear Staplers
Published on: August 21, 2021
Compression anastomosis for Roux-en-Y gastric bypass: observations in a large animal model
O N Tucker1, N Beglaibter, R J Rosenthal
1Bariatric Institute and Section of Minimally Invasive Surgery, Cleveland Clinic Florida, Weston, Florida, USA.
Summary
This study explored a new sutureless clip for gastric bypass surgery in pigs. The compression clip demonstrated safety and patency in gastrointestinal anastomoses, suggesting potential for reduced strictures in Roux-en-Y gastric bypass (RYGB).
Area of Science:
- Bariatric surgery
- Surgical innovation
- Gastrointestinal anastomosis
Background:
- Laparoscopic Roux-en-Y gastric bypass (RYGB) is effective for obesity and co-morbidities.
- Gastrojejunal anastomosis (GJA) strictures occur in ~3% of RYGB procedures.
- Sutureless anastomosis devices may reduce tissue trauma and stricture rates.
Purpose of the Study:
- To evaluate the safety of a Nitinol Compression Anastomosis Clip (CAC) for upper gastrointestinal anastomoses.
- To assess the CAC's efficacy in an animal model of open Roux-en-Y gastric bypass (RYGB).
Main Methods:
- A pilot study using an open RYGB model in six female pigs.
- Group 1: CAC for GJA, stapler for jejunojejunal anastomosis (JJA).
- Group 2: CAC for both GJA and JJA. Euthanasia at 1, 4, and 8 weeks.
Main Results:
- All anastomoses were patent post-mortem; no strictures observed at 2 months.
- CAC GJA diameter averaged 1.6 cm; stapled JJA averaged 3.8 cm; CAC JJA averaged 3 cm.
- Burst pressures were comparable between stapled and CAC anastomoses; device expelled by day 9.
Conclusions:
- Sutureless compression anastomoses using the CAC are safe in an RYGB animal model.
- The CAC shows potential for improving GJA patency and reducing strictures.
- Further research is warranted to explore clinical applications.
