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Updated: Jul 13, 2026
09:08
Integration of Bioinformatics Approaches and Experimental Validations to Understand the Role of Notch Signaling in Ovarian Cancer
Published on: January 12, 2020
Notch and cancer: a double-edged sword.
1The Swiss Institute for Experimental Cancer Research, Ecole Polytechnique Fédérale de Lausanne, Chemin des Boveresses 155, 1066 Epalinges, Switzerland.
Cellular and Molecular Life Sciences : CMLS
|August 10, 2007
Summary
The Notch signaling pathway regulates tissue development and stem cells. In cancer, it can promote or suppress tumors, prompting new therapeutic strategies targeting tumor growth and angiogenesis.
Area of Science:
- * Molecular biology
- * Developmental biology
- * Cancer research
Background:
- * The Notch signaling pathway is a highly conserved cell-cell communication system crucial for embryonic development and adult tissue homeostasis.
- * Its roles include stem cell maintenance, cell fate determination, and differentiation, processes often dysregulated in cancer.
- * Notch signaling exhibits context-dependent functions in cancer, acting as both an oncogene and a tumor suppressor.
Purpose of the Study:
- * To review recent advancements in understanding Notch signaling in cancer.
- * To explore the role of Notch signaling in tumor angiogenesis.
- * To highlight emerging therapeutic strategies targeting Notch signaling in cancer treatment.
Main Methods:
- * Review of current literature on Notch signaling in cancer.
- * Analysis of studies investigating Notch pathway involvement in tumor angiogenesis.
- * Examination of preclinical and clinical data on Notch-targeted therapies.
Main Results:
- * Notch signaling is implicated in various stages of tumorigenesis and metastasis.
- * The pathway significantly influences the tumor microenvironment, particularly angiogenesis.
- * Therapeutic interventions targeting Notch signaling show promise in preclinical models.
Conclusions:
- * Notch signaling is a complex regulator of cancer, with dual roles depending on the cellular context.
- * Targeting Notch signaling presents a viable therapeutic avenue for cancer treatment, especially in combination therapies.
- * Further research is needed to fully elucidate Notch's role in angiogenesis and optimize therapeutic strategies.
Related Concept Videos
03:14Notch Signaling Pathway
The Notch signaling pathway is a major intracellular signaling pathway that is highly conserved over a broad spectrum of metazoan species. It stands unique from other intracellular signaling mechanisms in animals because notch protein itself acts as the receptor as well as the primary signaling molecule.
The Notch gene came into the limelight in 1914 after the discovery that its mutation in Drosophila melanogaster leads to a serrated (or "notched") wing margin phenotype. It was not until 1985...
The Notch gene came into the limelight in 1914 after the discovery that its mutation in Drosophila melanogaster leads to a serrated (or "notched") wing margin phenotype. It was not until 1985...
03:14Notch Signaling Pathway
The Notch signaling pathway is a major intracellular signaling pathway that is highly conserved over a broad spectrum of metazoan species. It stands unique from other intracellular signaling mechanisms in animals because notch protein itself acts as the receptor as well as the primary signaling molecule.
The Notch gene came into the limelight in 1914 after the discovery that its mutation in Drosophila melanogaster leads to a serrated (or "notched") wing margin phenotype. It was not until 1985...
The Notch gene came into the limelight in 1914 after the discovery that its mutation in Drosophila melanogaster leads to a serrated (or "notched") wing margin phenotype. It was not until 1985...
02:18Cancer
Cancers arise due to mutations in genes involved in the regulation of cell division, which leads to unrestricted cell proliferation. Modern science and medicine have made great strides in the understanding and treatment of cancer, including eradicating cancer in some patients. However, there is still no cure for cancer. This is largely due to the fact that cancer is a large group of many diseases.
01:12Role Of Notch Signalling In Intestinal Stem Cell Renewal
Notch signaling was first discovered in Drosophila melanogaster, where it is involved in cell lineage differentiation. Notch signaling regulates the maintenance and differentiation of intestinal stem cells or ISCs by controlling the expression of atonal homolog 1 or Atoh1. Atoh1 directs cells to differentiate into secretory cells.
Direct cell-to-cell contact is needed for the activation of Notch signaling. The signal is initiated when a notch ligand binds to a receptor on an adjacent cell, also...
Direct cell-to-cell contact is needed for the activation of Notch signaling. The signal is initiated when a notch ligand binds to a receptor on an adjacent cell, also...
02:53Adaptive Mechanisms in Cancer Cells
Cancer cells accumulate genetic changes at an abnormally rapid rate due to the defects in the DNA repair mechanisms. From an evolutionary perspective, such genetic instability is advantageous for cancer development. Mutant cell lines accumulate a series of beneficial mutations that contribute to their progression into cancer.
Some of the advantages that cancer cells have on normal cells include - enhanced ability to divide without terminally differentiating, induce new blood vessel formation,...
Some of the advantages that cancer cells have on normal cells include - enhanced ability to divide without terminally differentiating, induce new blood vessel formation,...
02:53Adaptive Mechanisms in Cancer Cells
Cancer cells accumulate genetic changes at an abnormally rapid rate due to the defects in the DNA repair mechanisms. From an evolutionary perspective, such genetic instability is advantageous for cancer development. Mutant cell lines accumulate a series of beneficial mutations that contribute to their progression into cancer.
Some of the advantages that cancer cells have on normal cells include - enhanced ability to divide without terminally differentiating, induce new blood vessel formation,...
Some of the advantages that cancer cells have on normal cells include - enhanced ability to divide without terminally differentiating, induce new blood vessel formation,...