Related Experiment Video
Updated: Jul 13, 2026

On-Chip Endothelial Inflammatory Phenotyping
Published on: July 21, 2012
Relation between hypercholesterolaemia and vascular endothelial microinflammation
A S Elwakkad1, S I Mohamed, M Fathalla
1Department of Medical Physiology, National Research Centre, Giza, Egypt. amanyse@hotmail.com
Abstract:
We investigated the correlation between hypercholesterolaemia and oxidative stress and P-selectin and interleukin-6 (IL-6) as markers for endothelial status. We studied 40 Egyptian adults with asymptomatic hypercholesterolaemia and 20 age- and sex-matched controls. Lipid peroxidation was significantly higher (P < 0.001) in the study group and positively correlated with cholesterol (P < 0.001) and low-density lipoprotein (LDL) (P < 0.002). Glutathione peroxidase activity was also significantly higher (P < 0.001) with positive correlation with cholesterol (P < 0.001) and LDL (P < 0.001). Markers for endothelial cell function were significantly higher in the study group (P < 0.001) with a positive correlation with cholesterol (P < 0.001) and LDL (P < 0.001). Hypercholesterolaemia causes endothelial microinflammation, and P-selectin and IL-6 may also be risk factors for cardiovascular disease.
Related Concept Videos
Inflammation
Coronary Artery Disease II: Pathophysiology
Atherosclerosis I: Introduction
Cholesterol: Significance and Regulation
Considering cholesterol and...
Chronic Inflammation: Introduction
Acute Inflammation III: Local and Systemic Effects
